{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:28:45Z","timestamp":1792160925540,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010651","name":"Fujian Normal University","doi-asserted-by":"publisher","award":["I202102008"],"award-info":[{"award-number":["I202102008"]}],"id":[{"id":"10.13039\/501100010651","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010651","name":"Fujian Normal University","doi-asserted-by":"publisher","award":["I202003009"],"award-info":[{"award-number":["I202003009"]}],"id":[{"id":"10.13039\/501100010651","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010651","name":"Fujian Normal University","doi-asserted-by":"publisher","award":["2022 J01172"],"award-info":[{"award-number":["2022 J01172"]}],"id":[{"id":"10.13039\/501100010651","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010651","name":"Fujian Normal University","doi-asserted-by":"publisher","award":["2021 J02028"],"award-info":[{"award-number":["2021 J02028"]}],"id":[{"id":"10.13039\/501100010651","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010651","name":"Fujian Normal University","doi-asserted-by":"publisher","award":["2020 J01176"],"award-info":[{"award-number":["2020 J01176"]}],"id":[{"id":"10.13039\/501100010651","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010651","name":"Fujian Normal University","doi-asserted-by":"publisher","award":["2020-JYJ-37"],"award-info":[{"award-number":["2020-JYJ-37"]}],"id":[{"id":"10.13039\/501100010651","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010651","name":"Fujian Normal University","doi-asserted-by":"publisher","award":["2020 L3008"],"award-info":[{"award-number":["2020 L3008"]}],"id":[{"id":"10.13039\/501100010651","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010651","name":"Fujian Normal University","doi-asserted-by":"publisher","award":["2021G02028"],"award-info":[{"award-number":["2021G02028"]}],"id":[{"id":"10.13039\/501100010651","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010651","name":"Fujian Normal University","doi-asserted-by":"publisher","award":["2021G02021"],"award-info":[{"award-number":["2021G02021"]}],"id":[{"id":"10.13039\/501100010651","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["I202102008"],"award-info":[{"award-number":["I202102008"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["I202003009"],"award-info":[{"award-number":["I202003009"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2022 J01172"],"award-info":[{"award-number":["2022 J01172"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2021 J02028"],"award-info":[{"award-number":["2021 J02028"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2020 J01176"],"award-info":[{"award-number":["2020 J01176"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2020-JYJ-37"],"award-info":[{"award-number":["2020-JYJ-37"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2020 L3008"],"award-info":[{"award-number":["2020 L3008"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2021G02028"],"award-info":[{"award-number":["2021G02028"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2021G02021"],"award-info":[{"award-number":["2021G02021"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019971","name":"Luzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["I202102008"],"award-info":[{"award-number":["I202102008"]}],"id":[{"id":"10.13039\/501100019971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019971","name":"Luzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["I202003009"],"award-info":[{"award-number":["I202003009"]}],"id":[{"id":"10.13039\/501100019971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019971","name":"Luzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["2022 J01172"],"award-info":[{"award-number":["2022 J01172"]}],"id":[{"id":"10.13039\/501100019971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019971","name":"Luzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["2021 J02028"],"award-info":[{"award-number":["2021 J02028"]}],"id":[{"id":"10.13039\/501100019971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019971","name":"Luzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["2020 J01176"],"award-info":[{"award-number":["2020 J01176"]}],"id":[{"id":"10.13039\/501100019971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019971","name":"Luzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["2020-JYJ-37"],"award-info":[{"award-number":["2020-JYJ-37"]}],"id":[{"id":"10.13039\/501100019971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019971","name":"Luzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["2020 L3008"],"award-info":[{"award-number":["2020 L3008"]}],"id":[{"id":"10.13039\/501100019971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019971","name":"Luzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["2021G02028"],"award-info":[{"award-number":["2021G02028"]}],"id":[{"id":"10.13039\/501100019971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019971","name":"Luzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["2021G02021"],"award-info":[{"award-number":["2021G02021"]}],"id":[{"id":"10.13039\/501100019971","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Special Funds of the Central Government Guilding Local Science and Technology Development","award":["I202102008"],"award-info":[{"award-number":["I202102008"]}]},{"name":"Special Funds of the Central Government Guilding Local Science and Technology Development","award":["I202003009"],"award-info":[{"award-number":["I202003009"]}]},{"name":"Special Funds of the Central Government Guilding Local Science and Technology Development","award":["2022 J01172"],"award-info":[{"award-number":["2022 J01172"]}]},{"name":"Special Funds of the Central Government Guilding Local Science and Technology Development","award":["2021 J02028"],"award-info":[{"award-number":["2021 J02028"]}]},{"name":"Special Funds of the Central Government Guilding Local Science and Technology Development","award":["2020 J01176"],"award-info":[{"award-number":["2020 J01176"]}]},{"name":"Special Funds of the Central Government Guilding Local Science and Technology Development","award":["2020-JYJ-37"],"award-info":[{"award-number":["2020-JYJ-37"]}]},{"name":"Special Funds of the Central Government Guilding Local Science and Technology Development","award":["2020 L3008"],"award-info":[{"award-number":["2020 L3008"]}]},{"name":"Special Funds of the Central Government Guilding Local Science and Technology Development","award":["2021G02028"],"award-info":[{"award-number":["2021G02028"]}]},{"name":"Special Funds of the Central Government Guilding Local Science and Technology Development","award":["2021G02021"],"award-info":[{"award-number":["2021G02021"]}]},{"name":"Key Projects of Scientific and Technological Innovation in Fujian Province","award":["I202102008"],"award-info":[{"award-number":["I202102008"]}]},{"name":"Key Projects of Scientific and Technological Innovation in Fujian Province","award":["I202003009"],"award-info":[{"award-number":["I202003009"]}]},{"name":"Key Projects of Scientific and Technological Innovation in Fujian Province","award":["2022 J01172"],"award-info":[{"award-number":["2022 J01172"]}]},{"name":"Key Projects of Scientific and Technological Innovation in Fujian Province","award":["2021 J02028"],"award-info":[{"award-number":["2021 J02028"]}]},{"name":"Key Projects of Scientific and Technological Innovation in Fujian Province","award":["2020 J01176"],"award-info":[{"award-number":["2020 J01176"]}]},{"name":"Key Projects of Scientific and Technological Innovation in Fujian Province","award":["2020-JYJ-37"],"award-info":[{"award-number":["2020-JYJ-37"]}]},{"name":"Key Projects of Scientific and Technological Innovation in Fujian Province","award":["2020 L3008"],"award-info":[{"award-number":["2020 L3008"]}]},{"name":"Key Projects of Scientific and Technological Innovation in Fujian Province","award":["2021G02028"],"award-info":[{"award-number":["2021G02028"]}]},{"name":"Key Projects of Scientific and Technological Innovation in Fujian Province","award":["2021G02021"],"award-info":[{"award-number":["2021G02021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2023,2,3]]},"abstract":"<jats:p>Testes produce sperms, and gamete generation relies on a proper niche environment. The disruption of hierarchical regulatory homeostasis in Leydig or Sertoli cells may evoke a sterile phenotype in humans. In this study, we recapitulated type 2 diabetes mellitus by using a high-fat diet- (HFD-) fed mouse model to identify the phenotype and potential mechanism of diabetes-induced testicular impairment. At the end of the study, blood glucose levels, testosterone structure, testicular antioxidant capacity, and testosterone level and the expression of hypoxia-inducible factor- (HIF-) 1\u03b1, apoptosis-related protein cleaved-caspase3, and autophagy-related proteins such as LC3I\/II, p62, and Beclin1 were evaluated. We found that long-term HFD treatment causes the development of diabetes mellitus, implicating increased serum glucose level, cell apoptosis, and testicular atrophy (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula> vs. Ctrl). Mechanistically, the results showed enhanced expression of HIF-1\u03b1 in both Sertoli and Leydig cells (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula> vs. Ctrl). Advanced glycation end products (AGEs) were demonstrated to be a potential factor leading to HIF-1\u03b1 upregulation in both cell types. In Sertoli cells, high glucose treatment had minor effects on Sertoli cell autophagy. However, AGE treatment stagnated the autophagy flux and escalated cell apoptosis (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula> vs. Ctrl+Ctrl). In Leydig cells, high glucose treatment was adequate to encumber autophagy induction and enhance oxidative stress. Similarly, AGE treatment facilitated HIF-1\u03b1 expression and hampered testosterone production (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula> vs. Ctrl+Ctrl). Overall, these findings highlight the dual effects of diabetes on autophagy regulation in Sertoli and Leydig cells while imposing oxidative stress in both cell types. Furthermore, the upregulation of HIF-1\u03b1, which could be triggered by AGE treatment, may negatively affect both cell types. Together, these findings will help us further understand the molecular mechanism of diabetes-induced autophagy dysregulation and testicular impairment, enriching the content of male reproductive biology in diabetic patients.<\/jats:p>","DOI":"10.1155\/2023\/4365895","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T19:21:35Z","timestamp":1675452095000},"page":"1-12","source":"Crossref","is-referenced-by-count":31,"title":["Diabetes-Induced Autophagy Dysregulation Engenders Testicular Impairment via Oxidative Stress"],"prefix":"10.1155","volume":"2023","author":[{"given":"Renfeng","family":"Xu","sequence":"first","affiliation":[{"name":"Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[{"name":"Provincial University Key Laboratory of Sport and Health Science, School of Physical Education and Sport Sciences, Fujian Normal University, Fuzhou 350007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4309-0221","authenticated-orcid":true,"given":"Zhenghong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yedong","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China"},{"name":"Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen 361102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Bi","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen 361102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congjian","family":"Shi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Defan","family":"Wang","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University, Xiamen 361102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqin","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7439-9630","authenticated-orcid":true,"given":"Zhengchao","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou 350007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2015-9866","authenticated-orcid":true,"given":"Zonghao","family":"Tang","sequence":"additional","affiliation":[{"name":"Drug Discovery Research Center, Key Laboratory of Medical Electrophysiology, Ministry of Education, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China"},{"name":"Cedars-Sinai Medical Center, Los Angeles 90048, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)01188-9"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/nm-fertilityS33"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12366"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml056"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-018-0805-0"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19414-4"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnz013"},{"issue":"1","key":"8","first-page":"623","article-title":"The ultrastructural changes of the Sertoli and Leydig cells following streptozotocin induced diabetes","volume":"15","author":"D. Kianifard","year":"2012","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2015.07.001"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.09.058"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1071\/RD03089"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-018-2138-4"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-022-03615-z"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-014-0425-7"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.152"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.150"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2016.1159377"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201710078"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-018-2891-1"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7156579"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.11.007"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1764929"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.631016"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3809308"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.619924"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5278"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1111\/and.12363"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-013-0601-1"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2015.12.016"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.suppl_3.s215"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.008045"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-017-0338-8"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1530\/JME-18-0148"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.4161\/tisb.23992"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0956-4"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23915"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-1138-4"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abb9036"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.135871"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.01.013"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173132"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2018.1543329"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1111\/dme.13977"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111385"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1177\/0960327120909525"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-015-0166-x"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2010.146"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2023\/4365895.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2023\/4365895.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2023\/4365895.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T19:21:42Z","timestamp":1675452102000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/omcl\/2023\/4365895\/"}},"subtitle":[],"editor":[{"given":"Chen-he","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,2,3]]},"references-count":47,"alternative-id":["4365895","4365895"],"URL":"https:\/\/doi.org\/10.1155\/2023\/4365895","relation":{},"ISSN":["1942-0994","1942-0900"],"issn-type":[{"value":"1942-0994","type":"electronic"},{"value":"1942-0900","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2,3]]}}}