{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:24:20Z","timestamp":1777631060476,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["LORENZ22H0"],"award-info":[{"award-number":["LORENZ22H0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["HL145076"],"award-info":[{"award-number":["HL145076"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["P30-DK116073"],"award-info":[{"award-number":["P30-DK116073"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["LORENZ22H0"],"award-info":[{"award-number":["LORENZ22H0"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL145076"],"award-info":[{"award-number":["HL145076"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30-DK116073"],"award-info":[{"award-number":["P30-DK116073"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["LORENZ22H0"],"award-info":[{"award-number":["LORENZ22H0"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["HL145076"],"award-info":[{"award-number":["HL145076"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30-DK116073"],"award-info":[{"award-number":["P30-DK116073"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Diabetes"],"published-print":{"date-parts":[[2023,4,17]]},"abstract":"<jats:p>Background. In cystic fibrosis-related diabetes (CFRD) screening, oral glucose tolerance test (OGTT) thresholds for detecting prediabetes and diabetes are defined by the 2-hour glucose (2\u2009hG). Intermediate OGTT glucoses, between 0 and 2\u2009hours, that are \u2265200\u2009mg\/dL are deemed \u201cindeterminate,\u201d although lower 1-hour glucose (1\u2009hG) thresholds identify those at increased risk of type 2 diabetes in other populations, and may also better predict clinical decline in CF. Studies of 1\u2009hG thresholds &lt;200\u2009mg\/dL in people with CF are limited. Methods. A single center, retrospective chart review was performed of patients with 1\u2009hG available on OGTTs collected between 2010 and 2019. In patients with \u22652 OGTTs, Kaplan\u2013Meier analysis estimated likelihood of progression to CFRD based on a high vs. low 1\u2009hG. In patients with \u22651 OGTT, mixed-effects models tested whether baseline 1\u2009hG and 2\u2009hG predicted growth and lung function trajectories. Results. A total of 243 individuals with CF were identified with at least 1 OGTT including a 1\u2009hG, and n\u2009=\u2009177 had \u22652 OGTTs. Baseline age (mean\u2009\u00b1\u2009SD) was 12.4\u2009\u00b1\u20092.6\u2009years with 3.2\u2009\u00b1\u20091.4\u2009years of follow-up. Twenty-eight developed CFRD. All who developed CFRD had a 1\u2009hG\u2009\u2265\u2009155\u2009mg\/dL prior to 2\u2009hG\u2009&gt;\u2009140\u2009mg\/dL. The average 1\u2009hG was 267\u2009mg\/dL when 2\u2009hG\u2009\u2265\u2009200\u2009mg\/dL. In a subset with baseline 2\u2009hG\u2009&lt;\u2009140\u2009mg\/dL, 1\u2009hG\u2009\u2265\u2009140\u2009mg\/dL conferred an increased 5\u2009years risk of CFRD (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.036<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Baseline 2\u2009hG predicted decline in FEV1%predicted, but 1\u2009hG did not. Conclusions. In youth with CF, 1\u2009hG\u2009\u2265\u2009140\u2009mg\/dl is an early indicator of CFRD risk. However, 2\u2009hG, rather than 1\u2009hG, predicted lung function decline.<\/jats:p>","DOI":"10.1155\/2023\/4395556","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T17:51:23Z","timestamp":1681753883000},"page":"1-8","source":"Crossref","is-referenced-by-count":6,"title":["Predictive Value of 1-Hour Glucose Elevations during Oral Glucose Tolerance Testing for Cystic Fibrosis-Related Diabetes"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8044-3850","authenticated-orcid":true,"given":"Andrea N.","family":"Lorenz","sequence":"first","affiliation":[{"name":"Pediatric Endocrinology, Department of Pediatrics, Children\u2019s Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5577-8221","authenticated-orcid":true,"given":"Laura","family":"Pyle","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4173-2534","authenticated-orcid":true,"given":"Joon","family":"Ha","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Modeling, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8372-5941","authenticated-orcid":true,"given":"Arthur","family":"Sherman","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Modeling, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1593-1695","authenticated-orcid":true,"given":"Melanie","family":"Cree-Green","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Department of Pediatrics, Children\u2019s Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6172-4465","authenticated-orcid":true,"given":"Scott D.","family":"Sagel","sequence":"additional","affiliation":[{"name":"Breathing Institute, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0477-3356","authenticated-orcid":true,"given":"Kristen J.","family":"Nadeau","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Department of Pediatrics, Children\u2019s Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3067-7672","authenticated-orcid":true,"given":"Christine L.","family":"Chan","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Department of Pediatrics, Children\u2019s Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","volume-title":"Cystic Fibrosis Foundation Patient Registry","author":"Cystic Fibrosis Foundation","year":"2021"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.7326\/m13-0636"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(05)80032-0"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12732"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1994.tb13156.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1080\/08035250118974"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0585"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2013.06.001"},{"key":"9","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2020"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa592"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-016-0205-8"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcte.2021.100279"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.673539"},{"key":"14","article-title":"A north American provider survey of CFRD screening practices","author":"R. 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