{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:54:06Z","timestamp":1747191246040,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Breast Journal"],"published-print":{"date-parts":[[2023,1,4]]},"abstract":"<jats:p>Objective. To evaluate the efficiency and safety of sentinel lymph node biopsy (SLNB) in patients with breast cancer with complete response to neoadjuvant chemotherapy (NAC). Methods. Ninety-two consecutive (T1-4 and N1-2) patients with breast cancer who had pathologic and\/or clinical and radiologic axillary lymph node involvement were included. All patients received NAC. Patients with a clinical and radiologic complete response in the axilla after NAC underwent SLNB. Pathologic complete response (ypCR) was defined as the absence of residual invasive and in situ cancer, and near-complete response (ypNCR) represented in situ and\/or\u2009\u2264\u20091\u2009mm residual tumor in the breast and\/or presence of malignant cell clusters (\u22640.2\u2009mm) and\/or micrometastases (\u22642.0\u2009mm) in the axillary lymph nodes (ALN) (ypTis\/T1mi, ypN0i+\/pN1mi). Results. The mean age of the 92 patients was 49.6\u2009\u00b1\u200910.3\u2009years and the mean follow-up was 34.0\u2009\u00b1\u200917.8\u2009months. With respect to breast tumors, 23 (25.0%) patients had complete and 14 (15.2%) had a near-complete response to NAC. Complete response in ALN was obtained in 39 (42.4%) patients and near-complete in six (6.5%) patients. The overall survival of the 33 patients who achieved ypCR and ypNCR was 100% and the remaining 59 patients with partial or no response to NAC was 83.1% at a mean follow-up of 34\u2009months (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.063<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Conclusions. In this study, no event developed in cases with ypCR and ypNCR in the breast and axilla. The persistence of the same results in long-termfollow-ups may enable the use of ypNCR as a positive prognostic marker in addition to ypCR.<\/jats:p>","DOI":"10.1155\/2023\/4549033","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T21:20:08Z","timestamp":1672867208000},"page":"1-7","source":"Crossref","is-referenced-by-count":2,"title":["The Oncologic Safety of Sentinel Lymph Node Biopsy in Patients with Node-Positive Breast Cancer with Complete Response to Neoadjuvant Chemotherapy: A Single-Center Experience"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1299-081X","authenticated-orcid":true,"given":"Ismail Can","family":"Tercan","sequence":"first","affiliation":[{"name":"Department of General Surgery, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1812-6846","authenticated-orcid":true,"given":"Baha","family":"Zengel","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2520-5953","authenticated-orcid":true,"given":"Ozlem","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Izmir Bozyaka Health Practice and Research Center, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3278-3770","authenticated-orcid":true,"given":"Demet","family":"Cavdar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Izmir Bozyaka Health Practice and Research Center, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5145-0026","authenticated-orcid":true,"given":"Funda","family":"Tasli","sequence":"additional","affiliation":[{"name":"Department of Pathology, Izmir Bozyaka Health Practice and Research Center, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9265-8114","authenticated-orcid":true,"given":"Zehra Hilal","family":"Adibelli","sequence":"additional","affiliation":[{"name":"Department of Radiology, Izmir Bozyaka Health Practice and Research Center, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7957-9291","authenticated-orcid":true,"given":"Murat","family":"Karatas","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9296-0097","authenticated-orcid":true,"given":"Cenk","family":"Simsek","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1041-8462","authenticated-orcid":true,"given":"Isabel Raika","family":"Durusoy","sequence":"additional","affiliation":[{"name":"Department of Public Health, Ege University, Medical Faculty, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2697-472X","authenticated-orcid":true,"given":"Adam","family":"Uslu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"doi-asserted-by":"publisher","key":"1","DOI":"10.1016\/0014-2964(80)90352-7"},{"doi-asserted-by":"publisher","key":"2","DOI":"10.1016\/S1470-2045(17)30777-5"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.1200\/jco.2001.19.22.4224"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.1200\/jco.2008.19.2567"},{"doi-asserted-by":"publisher","key":"5","DOI":"10.1080\/14656566.2020.1746273"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1245\/s10434-019-07517-2"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.1002\/(sici)1097-0142(19990815)86:4<628::aid-cncr11>3.0.co;2-l"},{"doi-asserted-by":"publisher","key":"8","DOI":"10.1200\/jco.2011.40.8369"},{"doi-asserted-by":"publisher","key":"9","DOI":"10.1245\/s10434-020-09211-0"},{"doi-asserted-by":"publisher","key":"10","DOI":"10.1016\/j.ejso.2015.11.019"},{"doi-asserted-by":"publisher","key":"11","DOI":"10.1097\/sla.0000000000004562"},{"doi-asserted-by":"publisher","key":"12","DOI":"10.1016\/j.ejso.2020.10.014"},{"doi-asserted-by":"publisher","key":"13","DOI":"10.1200\/jco.2011.38.8595"},{"doi-asserted-by":"publisher","key":"14","DOI":"10.1016\/j.ejso.2021.06.024"},{"issue":"15","key":"15","article-title":"Nsabp 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