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Emerging SARS\u2010CoV\u20102 variants caused by distinctive mutations within the viral spike glycoprotein of SARS\u2010CoV\u20102 are considered the cause for the rapid spread of the disease and make it challenging to treat SARS\u2010CoV\u20102. The manufacturing of appropriate efficient vaccines and therapeutics is the only option to combat this pandemic. Nanomedicine has enabled the delivery of nucleic acids and protein\u2010based vaccines to antigen\u2010presenting cells to produce protective immunity against the coronavirus. Nucleic acid\u2010based vaccines, particularly mRNA nanotechnology vaccines, are the best prevention option against the SARS\u2010CoV\u20102 pandemic worldwide, and they are effective against the novel coronavirus and its multiple variants. This review will report on progress made thus far with SARS\u2010CoV\u20102 vaccines and beyond employing nanotechnology\u2010based nucleic acid vaccine approaches.<\/jats:p>","DOI":"10.1155\/2023\/4588659","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T21:08:23Z","timestamp":1683234503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Next\u2010Generation Vaccines: Nanovaccines in the Fight against SARS\u2010CoV\u20102 Virus and beyond SARS\u2010CoV\u20102"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2112-7137","authenticated-orcid":false,"given":"Maluta Steven","family":"Mufamadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7682-9489","authenticated-orcid":false,"given":"Mpho 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