{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:11:54Z","timestamp":1740143514154,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002839","name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002839","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007534","name":"B. 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To induce experimental myocarditis, five male rats (weight ~300\u2009g, age ~50 days) were treated with one application per week of doxorubicin (2\u2009mg\/kg BW) over a period of six weeks. Three control animals received the identical volume of sodium chloride 0.9% instead. Following week six, all animals received a single 4\u2009ml injection of an 20% oil-in-water perfluorooctylbromide nanoemulsion 24 hours prior to in vivo1H\/19F imaging on a 1.5\u2009Tesla MRI. After euthanasia, cardiac histology and immunohistochemistry using CD68\/ED1 macrophage antibodies were performed, measuring the inflamed myocardium in \u03bcm2 for further statistical analysis to compare the extent of the inflammation with the 19F-MRI signal intensity. All animals treated with doxorubicin showed a specific signal in the myocardium, while no myocardial signal could be detected in the control group. Additionally, the doxorubicin group showed a significantly higher SNR for 19F and a stronger CD68\/ED1 immunhistoreactivity compared to the control group. This proof-of-concept study demonstrates that perfluorocarbon nanoemulsions could be detected in an in vivo experimental myocarditis model at a currently clinically relevant field strength.<\/jats:p>","DOI":"10.1155\/2023\/4659041","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T20:50:08Z","timestamp":1689367808000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["In Vivo Fluorine Imaging Using 1.5 Tesla MRI for Depiction of Experimental Myocarditis in a Rodent Animal Model"],"prefix":"10.1155","volume":"2023","author":[{"given":"Thore","family":"Dietrich","sequence":"first","affiliation":[{"name":"Department of Cardiology, Deutsches Herzzentrum Berlin, Berlin 13353, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1150-6990","authenticated-orcid":true,"given":"Stephan Theodor","family":"Bujak","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Deutsches Herzzentrum Berlin, Berlin 13353, Germany"},{"name":"Department of Geriatrics, Krankenhaus Hedwigsh\u00f6he, Alexianer St. Hedwig Kliniken Berlin GmbH, Berlin 12526, Germany"},{"name":"Charit\u00e9-Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin 10117, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorsten","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Deutsches Herzzentrum Berlin, Berlin 13353, Germany"},{"name":"B. 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