{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:09:37Z","timestamp":1777392577971,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"vor","delay-in-days":52,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Critical Care Research and Practice"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Pulmonary barotrauma has been frequently observed in patients with COVID\u201019 who present with acute hypoxemic respiratory failure. This study evaluated the prevalence, risk factors, and outcomes of barotrauma in patients with COVID\u201019 requiring ICU admission. <jats:italic>Methods<\/jats:italic>. This retrospective cohort study included patients with confirmed COVID\u201019 who were admitted to an adult ICU between March and December 2020. We compared patients who had barotrauma with those who did not. A multivariable logistic regression analysis was performed to determine the predictors of barotrauma and hospital mortality. <jats:italic>Results<\/jats:italic>. Of 481 patients in the study cohort, 49 (10.2%, 95% confidence interval: 7.6\u201313.2%) developed barotrauma on a median of 4\u2009days after ICU admission. Barotrauma manifested as pneumothorax (<jats:italic>N<\/jats:italic>\u2009=\u200921), pneumomediastinum (<jats:italic>N<\/jats:italic>\u2009=\u200925), and subcutaneous emphysema (<jats:italic>N<\/jats:italic>\u2009=\u200925) with frequent overlap. Chronic comorbidities and inflammatory markers were similar in both patient groups. Barotrauma occurred in 4\/132 patients (3.0%) who received noninvasive ventilation without intubation, and in 43\/280 patients (15.4%) who received invasive mechanical ventilation. Invasive mechanical ventilation was the only risk factor for barotrauma (odds ratio: 14.558, 95% confidence interval: 1.833\u2013115.601). Patients with barotrauma had higher hospital mortality (69.4% versus 37.0%; <jats:italic>p<\/jats:italic> &lt; 0.0001) and longer duration of mechanical ventilation and ICU stay. Barotrauma was an independent predictor of hospital mortality (odds ratio: 2.784, 95% confidence interval: 1.310\u20135.918). <jats:italic>Conclusion<\/jats:italic>s. Barotrauma was common in critical COVID\u201019, with invasive mechanical ventilation being the most prominent risk factor. Barotrauma was associated with poorer clinical outcomes and was an independent predictor of hospital mortality.<\/jats:p>","DOI":"10.1155\/2023\/4675910","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T20:05:08Z","timestamp":1677096308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Occurrence, Risk Factors, and Outcomes of Pulmonary Barotrauma in Critically Ill COVID\u201019 Patients: A Retrospective Cohort Study"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3772-8949","authenticated-orcid":false,"given":"Hasan M.","family":"Al-Dorzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifa","family":"Almujaydia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reema","family":"Nazer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yara","family":"Alhusaini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aminah","family":"Alhamdan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajyad","family":"Al Jawad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.1585"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-2600(20)30079-5"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)30183-5"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)30211-7"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2021.103221"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020202352"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005283"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-022-06816-9"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/08850666211019719"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2021.09.018"},{"key":"e_1_2_12_11_2","unstructured":"National Institutes of Health Clinical spectrum of SARS-CoV-2 infection 2020 https:\/\/www.covid19treatmentguidelines.nih.gov\/overview\/clinical-spectrum\/."},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/1751-0473-3-17"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2018.10.033"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-037737"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2022.06.014"},{"key":"e_1_2_12_16_2","unstructured":"KouritasV. 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