{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:35:28Z","timestamp":1789792528748,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T00:00:00Z","timestamp":1685318400000},"content-version":"vor","delay-in-days":148,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>In Cameroon, malaria is still the cause of several deaths yearly and leading to the continued search for new potent leads to fight against <jats:italic>Plasmodium falciparum<\/jats:italic>. Medicinal plants like <jats:italic>Hypericum lanceolatum<\/jats:italic> Lam. are introduced in local preparations for the treatment of affected people. The bioassay\u2010guided fractionation of the crude extract of the twigs and stem bark of <jats:italic>H. lanceolatum<\/jats:italic> Lam. led to the identification of the dichloromethane\u2010soluble fraction as the most active (with 32.6% of the parasite <jats:italic>P. falciparum<\/jats:italic> 3D7 survival) which was further purified by successive column chromatography to obtain four compounds identified by their spectrometric data as two xanthones 1,6\u2010dihydroxyxanthone (<jats:bold>1<\/jats:bold>) and norathyriol (<jats:bold>2<\/jats:bold>) and two triterpenes betulinic acid (<jats:bold>3<\/jats:bold>) and ursolic acid (<jats:bold>4<\/jats:bold>). In the antiplasmodial assay against <jats:italic>P. falciparum<\/jats:italic> 3D7, the triterpenoids <jats:bold>3<\/jats:bold> and <jats:bold>4<\/jats:bold> displayed the most significant potencies with IC<jats:sub>50<\/jats:sub> values of 2.8 \u00b1 0.8\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL and 11.8 \u00b1 3.2\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL, respectively. Furthermore, both compounds were also the most cytotoxic against P388 cell lines with IC<jats:sub>50<\/jats:sub> values of 6.8 \u00b1 2.2\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL and 2.5 \u00b1 0.6\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL, respectively. Further insights on the inhibition method of the bioactive compounds and their drug\u2010likeness were obtained from their molecular docking and ADMET studies. The results obtained help in identifying additional antiplasmodial agents from <jats:italic>H. lanceolatum<\/jats:italic> and support its use in folk medicine for the treatment of malaria. The plant might be considered as a promising source of new antiplasmodial candidates in new drug discovery.<\/jats:p>","DOI":"10.1155\/2023\/4693765","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T06:25:47Z","timestamp":1685514347000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Bioassay\u2010Guided Isolation of Antiplasmodial Compounds from <i>Hypericum lanceolatum<\/i> Lam. 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