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To investigate the biodistribution and kinetic constants of 68Ga-DOTATATE in normal organs through dynamic total-body positron emission tomography\/computed tomography (PET\/CT). Methods. Seven patients who experienced endoscopic resection of gastric neuroendocrine tumor were enrolled. Dynamic total-body PET\/CT scans over 60\u2009min were performed. Time-activity curves were obtained by drawing regions of interest in normal organs. Rate constants, including K1, k2, k3, and vB, were computed using a two-tissue compartment model. Factor analysis was used to compare the rate constants among subjects and regions. Hierarchical cluster analysis was performed to identify organs with similar kinetic characteristics. Results. The highest uptake of 68Ga-DOTATATE was observed in the spleen followed by kidneys, adrenals, liver, pituitary gland, pancreas head, prostate, pancreas body, and thyroid, parotid, and submandibular glands. Low background level of 68Ga-DOTATATE uptake was observed in the nasal mucosa, bone, blood pool, and cerebrum. In addition, the uptake in the pancreas head was noted to be higher than the pancreas body (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) on the basis of each time point of dynamic PET. There were differences of rate constants among different organs. The mean K1 ranged from 0.0507\u2009min\u22121 in the left nasal mucosa to 1.21\u2009min\u22121 in the left kidney, and mean k2 ranged from 0.0174\u2009min\u22121 in the spleen to 4.4487\u2009min\u22121 in the left cerebrum. The mean k3 ranged from 0.0563\u2009min\u22121 in the right cerebrum to 4.6309\u2009min\u22121 in the left adrenal, and mean vB ranged from 0.0001 in the left cerebrum to 0.2489 in the right adrenal. However, none of the rate constants was significantly different among subjects or among different sites within a single organ. Three groups of organs with similar kinetic characteristics were identified: (1) cerebrum; (2) pituitary gland, liver, adrenal, and prostate; and (3) nasal mucosa, parotid and submandibular glands, thyroid, spleen, pancreas, kidney, and bone. Conclusion. Uptake and clearance of 68Ga-DOTATATE, in terms of kinetic constants, were different in different organs. The kinetic parameters of 68Ga-DOTATATE in different organs provide a reference for future dynamic PET imaging.<\/jats:p>","DOI":"10.1155\/2023\/4722499","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T01:35:08Z","timestamp":1674092108000},"page":"1-11","source":"Crossref","is-referenced-by-count":15,"title":["Dynamic Total-Body PET\/CT Imaging Reveals Kinetic Distribution of 68Ga-DOTATATE in Normal Organs"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0145-5643","authenticated-orcid":true,"given":"Hongyan","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China"},{"name":"Institute of Nuclear Medicine, Fudan University, Shanghai 200032, China"},{"name":"Shanghai Institute of Medical Imaging, Shanghai 200032, China"},{"name":"Cancer Prevention and Treatment Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7046-2353","authenticated-orcid":true,"given":"Guobing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China"},{"name":"Institute of Nuclear Medicine, Fudan University, Shanghai 200032, China"},{"name":"Shanghai Institute of Medical Imaging, Shanghai 200032, China"},{"name":"Cancer Prevention and Treatment Center, Zhongshan Hospital, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China"},{"name":"Institute of Nuclear Medicine, Fudan University, Shanghai 200032, China"},{"name":"Shanghai Institute of Medical Imaging, Shanghai 200032, China"},{"name":"Cancer Prevention 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