{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:07:49Z","timestamp":1785208069473,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["202102010149"],"award-info":[{"award-number":["202102010149"]}],"id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Biliary atresia (BA) is a type of severe cholestatic childhood disease that may have a genetic component. <jats:italic>miR-100<\/jats:italic> plays a key role in regulating cell apoptosis, proliferation, and inflammatory reactions. A single\u2010nucleotide polymorphism in <jats:italic>miR-100<\/jats:italic> has been proven to modulate susceptibility to various diseases. <jats:italic>Methods<\/jats:italic>. We conducted a case\u2010control retrospective study to explore the correlation between <jats:italic>miR-100<\/jats:italic> gene polymorphism (rs1834306 A&gt;G) and biliary atresia susceptibility in 484 Chinese patients and 1445 matched control subjects. <jats:italic>Results<\/jats:italic>. Our results showed that rs1834306 A&gt;G was correlated with a significantly increased risk for BA (GG vs. AA: adjusted\u2009odds\u2009ratio\u2009(OR) = 1.44, 95<jats:italic>%<\/jats:italic>confidence\u2009interval\u2009(CI) = 1.02\u20132.03, <jats:italic>p<\/jats:italic> = 0.041; and GG vs. AA\/AG: adjusted\u2009OR = 1.39, 95<jats:italic>%<\/jats:italic>CI = 1.02\u20131.89, <jats:italic>p<\/jats:italic> = 0.036). <jats:italic>Conclusions<\/jats:italic>. Our results showed that the rs1834306 A&gt;G polymorphism is associated with an increased risk for BA and contributes to BA susceptibility.<\/jats:p>","DOI":"10.1155\/2023\/4835839","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T20:05:16Z","timestamp":1672862716000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>MiR-100<\/i> rs1834306 A&gt;G Increases Biliary Atresia Risk in Southern Han Chinese 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