{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:54:36Z","timestamp":1747191276768,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T00:00:00Z","timestamp":1692662400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Cardiology"],"published-print":{"date-parts":[[2023,8,22]]},"abstract":"<jats:p>Background. Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary arterial hypertension characterized by diffuse venous vasculopathy and increased pulmonary vascular resistance resulting in right-sided heart failure. Case Presentation. A 22-year-old female patient started to have dyspnea with minimal effort and was diagnosed to have pre-capillary pulmonary hypertension (PH) with right-sided heart failure. Initially, she was diagnosed to have idiopathic PH. She developed life-threatening pulmonary oedema and cardiogenic shock after pulmonary vasodilator therapy. A genetic study was done and revealed the eukaryotic translation initiation factor 2 alpha kinase 4 (EIF2AK4) gene on chromosome 15, which was diagnostic to heritable PVOD. After failure to achieve hemodynamic stabilization with conventional cardiopulmonary support measures, extracorporeal membrane oxygenation (ECMO) supported her till bilateral lung transplantation, which was unfortunately complicated by acute graft rejection. After a prolonged intensive care unit stay with 4-month ECMO support, the second bilateral lung transplantation was done, and the patient survived and was discharged. Conclusions. Clinical recognition of PVOD is crucial due to its challenging diagnosis, need for genetic study, rapid deterioration with pulmonary vasodilators, and bad prognosis. Lung transplantation is the definitive treatment for eligible candidates.<\/jats:p>","DOI":"10.1155\/2023\/4846338","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T22:50:14Z","timestamp":1692744614000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["A Challenging Case of Genetically and Histologically Diagnosed Pulmonary Veno-Occlusive Disease with Extracorporeal Life Support and Redo Lung Transplantation"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5069-2813","authenticated-orcid":true,"given":"Mohamed","family":"Laimoud","sequence":"first","affiliation":[{"name":"Cardiac Surgery Critical Care Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia"},{"name":"Critical Care Medicine Department, Cairo University, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6159-8435","authenticated-orcid":true,"given":"Ziyad","family":"Alanazi","sequence":"additional","affiliation":[{"name":"Royal College of Surgeons in Ireland, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0128-1495","authenticated-orcid":true,"given":"Fayez","family":"Alahmadi","sequence":"additional","affiliation":[{"name":"Pulmonary Medicine Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9658-081X","authenticated-orcid":true,"given":"Abdullah","family":"Aldalaan","sequence":"additional","affiliation":[{"name":"Pulmonary Medicine Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00879-2022"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913-2018"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01032-2015"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.84"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00026-2016"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2844"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/bf01230858"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000209834.69972.e5"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31818193bb"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.73.4.1351"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1378\/chest.113.1.237"},{"issue":"6","key":"12","first-page":"1671","article-title":"Pulmonary veno-occlusive disease: a case series and new observations","volume":"118","author":"B. 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