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In previous studies, we found that the mutant somatic nuclear autoantigenic sperm protein (sNASP) gene in the mouse lupus susceptibility locus Sle2 can promote the development of lupus model mice, but the mechanism is still unclear. Here, we stimulated mouse peritoneal macrophages with different concentrations of lipopolysaccharide. The results showed that sNASP gene mutations can promote the response of the TLR4\u2013TAK1 signaling pathway but have no significant effect on the TLR4\u2013TBK1 signaling pathway. sNASP mutations enhanced TLR4-mediated nuclear factor-\u03ba-gene binding and mitogen-activated protein kinase activation and IL-6, tumor necrosis factor secretion in murine peritoneal macrophages. Collectively, our study revealed the impact of sNASP gene mutation on the sensitivity of TLR4 receptors in mouse peritoneal macrophages and shed light on potential mechanisms underlying inflammation in autoimmune diseases.<\/jats:p>","DOI":"10.1155\/2023\/4877700","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T19:17:16Z","timestamp":1695237436000},"page":"1-14","source":"Crossref","is-referenced-by-count":2,"title":["sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE by TAK1 Pathway"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4509-7713","authenticated-orcid":true,"given":"Yatao","family":"Bao","sequence":"first","affiliation":[{"name":"School of Basic Medical Science, Weifang Medical University, Weifang 261053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Lian","sequence":"additional","affiliation":[{"name":"School of Basic Medical Science, Weifang Medical University, Weifang 261053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Basic Medical Science, Weifang Medical University, Weifang 261053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaotian","family":"Gu","sequence":"additional","affiliation":[{"name":"School of Basic Medical Science, Weifang Medical University, Weifang 261053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunyu","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Basic Medical Science, Weifang Medical University, Weifang 261053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3774-8672","authenticated-orcid":true,"given":"Xiaoping","family":"Du","sequence":"additional","affiliation":[{"name":"Medical Control Office, The Second Affiliated Hospital of Weifang Medical University, Weifang 261041, China"},{"name":"Medical Control Office, Weifang, No. 2 Hospital, Weifang 261041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2874-3757","authenticated-orcid":true,"given":"Jiyu","family":"Ju","sequence":"additional","affiliation":[{"name":"School of Basic Medical Science, Weifang Medical University, Weifang 261053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","volume-title":"Systemic Lupus Erythematosus","author":"A. 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