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Exposure to air pollution stimulates reactive oxygen species (ROS) production in the body, which can further cause oxidative stress. Antioxidant enzymes, such as glutathione S-transferase mu 1 (GSTM1), are essential to prevent oxidative stress development by neutralizing excess oxidants. When the antioxidant enzyme function is lacking, ROS can accumulate and, thus, cause oxidative stress. Genetic variation studies from different countries show that GSTM1 null genotype dominates the GSTM1 genotype in the population. However, the impact of the GSTM1 null genotype in modifying the association between air pollution and health problem is not yet clear. This study will elaborate on GSTM1\u2019s null genotype role in modifying the relationship between air pollution and health problems.<\/jats:p>","DOI":"10.1155\/2023\/4961487","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T03:05:36Z","timestamp":1675739136000},"page":"1-13","source":"Crossref","is-referenced-by-count":9,"title":["A Review of the GSTM1 Null Genotype Modifies the Association between Air Pollutant Exposure and Health Problems"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1616-3053","authenticated-orcid":true,"given":"Dwi Aris Agung","family":"Nugrahaningsih","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hevi","family":"Wihadmadyatami","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitarina","family":"Widyarini","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahmi Ayu","family":"Wijayaningsih","sequence":"additional","affiliation":[{"name":"Master of Biomedical Science Program, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","volume-title":"Diseases and Air Pollution WHO European High-Level Conference on Noncommunicable Diseases Time to Deliver: Meeting NCD Targets to Achieve","author":"Who","year":"2019"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11274-8"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1177\/2397847318794859"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/487074"},{"issue":"1","key":"5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11869-010-0095-2","article-title":"Air pollution and circulating biomarkers of oxidative stress","volume":"4","author":"R. 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