{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:14:55Z","timestamp":1790190895065,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971484"],"award-info":[{"award-number":["81971484"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171754"],"award-info":[{"award-number":["82171754"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:p>Ras homolog gene family member A (RhoA) plays a major role in the Wnt\/planar cell polarity (PCP) pathway, which is significantly activated in patients with rheumatoid arthritis (RA). The function of RhoA in RA synovitis and bone erosion is still elusive. Here, we not only explored the impact of RhoA on the proliferation and invasion of RA fibroblast-like synoviocytes (FLSs) but also elucidated its effect on mouse osteoclast and a mouse model of collagen-induced arthritis (CIA). Results showed that RhoA was overexpressed in RA and CIA synovial tissues. Lentivirus-mediated silencing of RhoA increased apoptosis, attenuated invasion, and dramatically upregulated osteoprotegerin\/receptor activator of nuclear factor-\u03baB ligand (OPG\/RANKL) ratio in RA-FLSs. Additionally, the silencing of RhoA inhibited mouse osteoclast differentiation in vitro and alleviated synovial hyperplasia and bone erosion in the CIA mouse model. These effects in RA-FLSs and osteoclasts were all regulated by RhoA\/Rho-associated protein kinase 2 (ROCK2) and might interact with Janus kinase\/signal transducer and activator of transcription (JAK\/STAT) pathways.<\/jats:p>","DOI":"10.1155\/2023\/5057009","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T01:05:07Z","timestamp":1698887107000},"page":"1-15","source":"Crossref","is-referenced-by-count":11,"title":["RhoA Promotes Synovial Proliferation and Bone Erosion in Rheumatoid Arthritis through Wnt\/PCP Pathway"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8768-4246","authenticated-orcid":true,"given":"Ning","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Changhai Hospital, Naval Medical University, Shanghai, China"},{"name":"Department of Rheumatology and Immunology, The First People\u2019s Hospital of Yancheng, The Fourth Affiliated Hospital of Nantong University, Yancheng, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5053-9184","authenticated-orcid":true,"given":"Chao-Yue","family":"Diao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Changhai Hospital, Naval Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0620-877X","authenticated-orcid":true,"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Xing","family":"Tan","sequence":"additional","affiliation":[{"name":"Air Force Health Care Center for Special Services, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9323-2123","authenticated-orcid":true,"given":"Ya-Bing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Changhai Hospital, Naval Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5700-0461","authenticated-orcid":true,"given":"Xin-Yu","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Changhai Hospital, Naval Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1075-3631","authenticated-orcid":true,"given":"Jie","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Changhai Hospital, Naval Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5171-196X","authenticated-orcid":true,"given":"Dong-Bao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Changhai Hospital, Naval Medical University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.1"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.102400"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00859.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1004965"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.2174\/1874312901206010259"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2016.67"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1122"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3390\/biom11010048"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-009-0208-7"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215582"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-207137"},{"issue":"4","key":"12","first-page":"943","article-title":"Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis","volume":"152","author":"E. M. Gravallese","year":"1998","journal-title":"The American Journal of Pathology"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.153"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1760809"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.25"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2013.04.002"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00857.x"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.555245"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.414441"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20225552"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.3390\/cells8070733"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2022.2067984"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-051914-022120"},{"issue":"2","key":"24","first-page":"77","article-title":"Small molecule inhibition of cytoskeletal dynamics in melanoma tumors results in altered transcriptional expression patterns of key genes involved in tumor initiation and progression","volume":"8","author":"C. Spencer","year":"2011","journal-title":"Cancer Genomics Proteomics"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15172"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-020-01193-1"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1038\/srep28915"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205234"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20180541"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.3892\/etm"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-1935-6"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2019.372"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1207789109"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000181"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.042308.113308"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1002\/art.21548"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aan0023"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2017.4008"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-95839-1"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0244187"},{"issue":"11","key":"43","first-page":"3645","article-title":"Rho kinase proteins--pleiotropic modulators of cell survival and apoptosis","volume":"31","author":"C. A. Street","year":"2011","journal-title":"Anticancer Research"},{"key":"44","first-page":"333","article-title":"IL-23\/IL-17 axis in the pathogenesis and treatment of systemic lupus erythematosus and rheumatoid arthritis","volume":"42","author":"A. Farah Izati","year":"2020","journal-title":"Malaysian Journal of Pathology"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104513"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1038\/nature01658"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1038\/36593"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-020-01162-6"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.121764"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.223297"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313973200"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00369-6"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1414189111"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2016.10.001"},{"key":"55","first-page":"269","article-title":"Wnt\/\u03b2-catenin and LIF-Stat3 signaling pathways converge on Sp5 to promote mouse embryonic stem cell self-renewal","volume":"129","author":"S. Ye","year":"2016","journal-title":"Journal of Cell Science"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046892"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a031245"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020905"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay4447"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2023\/5057009.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2023\/5057009.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2023\/5057009.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T03:57:18Z","timestamp":1700711838000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/mi\/2023\/5057009\/"}},"subtitle":[],"editor":[{"given":"Fumio","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,11,1]]},"references-count":59,"alternative-id":["5057009","5057009"],"URL":"https:\/\/doi.org\/10.1155\/2023\/5057009","relation":{},"ISSN":["1466-1861","0962-9351"],"issn-type":[{"value":"1466-1861","type":"electronic"},{"value":"0962-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11,1]]}}}