{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:35:38Z","timestamp":1780504538791,"version":"3.54.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":68,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dentistry"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>\n                    <jats:italic>Introduction<\/jats:italic>\n                    . McArdle\u2019s disease is a severe glycogen storage disease characterized by intolerance to exercise; patients have a syndrome of muscle intolerance to stress, associated with myalgia, cramps, fatigue, and muscle weakness. Periodontal disease is a multifactorial pathology of the supporting tissues of the teeth: one of the main factors is the formation of bacterial biofilm; its control favors the prevention and the maintenance of good health of the oral cavity; and some systemic pathologies can worsen the periodontal disease and hinder its therapy. This case report concerns a woman with McArdle\u2019s disease diagnosed with periodontal disease.\n                    <jats:italic>Material and Methods<\/jats:italic>\n                    . A 54\u2010year\u2010old female patient with McArdle\u2019s disease has been diagnosed with Stage 3 generalized periodontitis, Grade B. At the baseline, the patient had 82 pockets with probing pocket depth (PPD) equal to or greater than 4\u2009mm. The patient was instructed in the correct methods of oral hygiene and was advised toothpaste and mouthwash based on probiotics; subsequently, a debridement was performed to remove etiological factors using Dental\u2010Biofilm Detection Topographic Technique (D\u2010BioTECH).\n                    <jats:italic>Results<\/jats:italic>\n                    . After 60 days, the number of pockets was reduced from 82 to 14 overall with PPD \u2265 4\u2009mm and from 50 to 2 pockets with PPD \u2265 5\u2009mm. Full mouth bleeding score (FMBS) increased from 48% to 15% and full mouth plaque score (FMPS) from 73% to 15%.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . In this case, the use of a correct brushing method combined with the D\u2010BioTECH has reduced the disease state, with the use of probiotics at home to restore and maintain a healthy oral microbiome.\n                  <\/jats:p>","DOI":"10.1155\/2023\/5080384","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T15:05:14Z","timestamp":1678460714000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Personalized Treatment of Periodontitis in a Patient with McArdle\u2019s Disease: The Benefits from Probiotics"],"prefix":"10.1155","volume":"2023","author":[{"given":"Salvatore","family":"Cannizzaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Maiorani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2760-0124","authenticated-orcid":false,"given":"Andrea","family":"Scribante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2457-4415","authenticated-orcid":false,"given":"Andrea","family":"Butera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20235919"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.7.923"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-301593"},{"key":"e_1_2_10_4_2","first-page":"718","article-title":"The prevalence and genetic characteristics of McArdle\u2019s disease in the Netherlands","volume":"12","author":"van Alfen N.","year":"2002","journal-title":"Neuromuscular Disorders"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/app10196720"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-018-0182-3"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.895537"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-022-00343-7"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.01031.x"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ma14040804"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9123914"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12995"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12155"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58040537"},{"key":"e_1_2_10_15_2","volume-title":"StatPearls","author":"Khattak Z. 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