{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:25:53Z","timestamp":1767169553681,"version":"build-2238731810"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>The action mechanism in which circular RNA (circ) SMARCA5 targeted nasopharyngeal carcinoma (NPC) cell proliferation, migration, invasion, and apoptosis via microRNA (miR)\u2010582\u20103p\/phosphatase and tensin homolog (PTEN) axis was explored. The examination was performed via reverse transcription\u2010quantitative polymerase chain reaction (RT\u2010qPCR), discovering that circSMARCA5 was elevated while miR\u2010582\u20103p was silenced in NPC tissues and cells. E\u2010cadherin and N\u2010cadherin were detected. The results illustrated transfection with si\u2010circSMARCA5 or miR\u2010582\u20103p\u2010mimic was available to repress cancer cell advancement, and E\u2010cadherin was augmented. Transfection with pcDNA 3.1\u2010circSMARCA5 or miR\u2010582\u20103p\u2010inhibitor was available to accelerate cancer cell advancement, and N\u2010cadherin was augmented. MiR\u2010582\u20103p\u2010inhibitor blocked the suppression of si\u2010circSMARCA5 on NPC. The si\u2010PTEN blocked the malignant behavior of pcDNA 3.1\u2010circSMARCA5 against NPC. The binding sites between circSMARCA5 and miR\u2010582\u20103p and between miR\u2010582\u20103p and PTEN were verified. Linear analysis results illuminated the expression pattern of circSMARCA5 was opposite to miR\u2010582\u20103p, while the expression pattern of circSMARCA5 was positively associated with PTEN. In brief, the results of the research clarified circSMARCA5 modulated NPC cells\u2019 vital movement via the miR\u2010582\u20103p\/PTEN molecular axis.<\/jats:p>","DOI":"10.1155\/2023\/5177471","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T14:05:46Z","timestamp":1673618746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["[Retracted] Circular RNA SMARCA5 Modulates Epithelial\u2010Mesenchymal Transformation, Proliferation, and Metastasis of Nasopharyngeal Carcinoma Cells via microRNA\u2010582\u20103p\/Phosphatase and Tensin Homolog 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