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According to recent studies, amyloid-\u03b2 (A\u03b2) isoforms as cerebrospinal fluid (CSF) biomarkers have remarkable predictive value for cognitive decline in the early stages of Alzheimer\u2019s disease (AD). Herein, we aimed to investigate the correlations between several targeted proteomics in CSF samples with A\u03b2 ratios and cognitive scores in patients in AD spectrum to search for potential early diagnostic utility. Methods. A total of 719 participants were found eligible for inclusion. Patients were then categorized into cognitively normal (CN), mild cognitive impairment (MCI), and AD and underwent an assessment of A\u03b2 and proteomics. Clinical Dementia Rating (CDR), Alzheimer\u2019s Disease Assessment Scale (ADAS), and Mini Mental State Exam (MMSE) were used for further cognitive assessment. The A\u03b242, A\u03b242\/A\u03b240, and A\u03b242\/38 ratios were considered as means of comparison to identify those peptides corresponding significantly to these established biomarkers and cognitive scores. The diagnostic utility of the IASNTQSR, VAELEDEK, VVSSIEQK, GDSVVYGLR, EPVAGDAVPGPK, and QETLPSK was assessed. Results. All investigated peptides corresponded significantly to A\u03b242 in controls. In those with MCI, VAELEDEK and EPVAGDAVPGPK were significantly correlated with A\u03b242 (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula> value &lt; 0.001). Additionally, IASNTQSR, VVSSIEQK, GDSVVYGLR, and QETLPSK were significantly correlated with A\u03b242\/A\u03b240 and A\u03b242\/38 (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                     <\/c:math>\n                  <\/jats:inline-formula> value &lt; 0.001) in this group. This group of peptides similarly corresponded to A\u03b2 ratios in those with AD. Eventually, IASNTQSR, VAELEDEK, and VVSSIEQK were significantly associated with CDR, ADAS-11, and ADAS-13, particularly in MCI group. Conclusion. Our research suggests potential early diagnostic and prognostic utilities for certain peptides extracted from CSF-targeted proteomics research. The ethical approval of ADNI is available at ClinicalTrials.gov with Identifier: NCT00106899.<\/jats:p>","DOI":"10.1155\/2023\/5336273","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T18:20:05Z","timestamp":1675707605000},"page":"1-9","source":"Crossref","is-referenced-by-count":3,"title":["CSF-Targeted Proteomics Indicate Amyloid-Beta Ratios in Patients with Alzheimer\u2019s Dementia Spectrum"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4125-845X","authenticated-orcid":true,"given":"Maryam","family":"Behzad","sequence":"first","affiliation":[{"name":"NeuroTRACT Association, Students\u2019 Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Chemistery, University of Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5277-2139","authenticated-orcid":true,"given":"Negin","family":"Zirak","sequence":"additional","affiliation":[{"name":"NeuroTRACT Association, Students\u2019 Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Educational Science and Psychology, University of Tabriz, Tabriz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6131-0120","authenticated-orcid":true,"given":"Ghazal Hamidi","family":"Madani","sequence":"additional","affiliation":[{"name":"NeuroTRACT Association, Students\u2019 Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Biology, Faculty of Sciences, University of Guilan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Baidoo","sequence":"additional","affiliation":[{"name":"NeuroTRACT Association, Students\u2019 Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Rezaei","sequence":"additional","affiliation":[{"name":"NeuroTRACT Association, Students\u2019 Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8948-4210","authenticated-orcid":true,"given":"Shima","family":"Karbasi","sequence":"additional","affiliation":[{"name":"NeuroTRACT Association, Students\u2019 Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"NeuroTRACT Association, Students\u2019 Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3520-1553","authenticated-orcid":true,"given":"Mahan","family":"Shafie","sequence":"additional","affiliation":[{"name":"NeuroTRACT Association, Students\u2019 Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4656-156X","authenticated-orcid":true,"given":"Mahsa","family":"Mayeli","sequence":"additional","affiliation":[{"name":"NeuroTRACT Association, Students\u2019 Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"School of Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[{"name":"Alzheimer\u2019s Disease Neuroimaging Initiative, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"doi-asserted-by":"publisher","key":"1","DOI":"10.3390\/proteomes9030036"},{"doi-asserted-by":"publisher","key":"2","DOI":"10.1016\/j.nurpra.2017.10.014"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.1002\/prca.201800105"},{"issue":"1","key":"4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/ene.13439","article-title":"Alzheimer\u2019s disease","volume":"25","author":"C. 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