{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:43:34Z","timestamp":1790718214932,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Tropical Medicine"],"published-print":{"date-parts":[[2023,9,8]]},"abstract":"<jats:p>The present study was done to evaluate the prevalence of intestinal parasitic infections (IPIs) in patients with COVID-19 in health care centers (Imam Reza and Golestan hospitals), Tehran, capital of Iran. By designing a matched case-control study, 200 fecal samples were collected for each of the COVID-19 patients and healthy individuals. Nasopharyngeal\/oropharyngeal swab samples were collected from all participants for the diagnosis of COVID-19. RNA extraction was performed, and then real time reverse-transcription polymerase chain reaction (rRT-PCR) assay was applied to detect viral RNA. Considering the lung complications, 25%&gt; lung complications was detected in 49 patients, 25\u201349% in 42 patients, and 50%\u2264 in 109 patients. Fecal samples were examined using different parasitological techniques. After nested-PCR, sequencing was applied to identify Cryptosporidium spp. and microsporidia spp. A relatively lower prevalence of IPIs was detected among control group (7.5%), than in COVID-19 patients (13%), though not significant <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mfenced open=\"(\" close=\")\" separators=\"|\">\n                           <a:mrow>\n                              <a:mi>P<\/a:mi>\n                              <a:mo>=<\/a:mo>\n                              <a:mn>0.13<\/a:mn>\n                           <\/a:mrow>\n                        <\/a:mfenced>\n                     <\/a:math>\n                  <\/jats:inline-formula>. The most prevalent parasite among patients was Blastocystis sp. (6%). Also, 13.76% of IPIs were detected in inpatients with more than 50% lung complication. As well, a remarkably significant difference in IPIs was observed among diarrheic COVID-19 patients, in comparison with nondiarrheic patients <jats:inline-formula>\n                     <f:math xmlns:f=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <f:mfenced open=\"(\" close=\")\" separators=\"|\">\n                           <f:mrow>\n                              <f:mi>P<\/f:mi>\n                              <f:mo>&lt;<\/f:mo>\n                              <f:mn>0.00001<\/f:mn>\n                           <\/f:mrow>\n                        <\/f:mfenced>\n                     <\/f:math>\n                  <\/jats:inline-formula>. Moreover, the isolated sequences in the present study belonged to C. parvum subtype IIa and Enterocytozoon bieneusi genotypes D and Peru 8. In conclusion, more epidemiological and clinical research studies are needed to better understand the status and interaction of IPI in COVID-19 in Iran and other countries.<\/jats:p>","DOI":"10.1155\/2023\/5359823","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T23:20:07Z","timestamp":1694215207000},"page":"1-7","source":"Crossref","is-referenced-by-count":2,"title":["The Frequency of Intestinal Parasitic Infections in COVID-19 Patients: A Case-Control Study in Tehran, Capital of Iran"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6876-5902","authenticated-orcid":true,"given":"Ali","family":"Taghipour","sequence":"first","affiliation":[{"name":"Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-4772","authenticated-orcid":true,"given":"Majid","family":"Pirestani","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3213-0948","authenticated-orcid":true,"given":"Ramin","family":"Hamidi Farahani","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Center, AJA University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8304-8477","authenticated-orcid":true,"given":"Mohammad","family":"Barati","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Center, AJA University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3345\/cep.2020.00493"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2020.07.011"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)30183-5"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)30566-3"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)31189-2"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.5394"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.15167\/2421-4248\/jpmh2021.62.2.1627"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0251170"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.4197\/med.16-1.4"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6669742"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(18)32279-7"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001921"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0223722"},{"issue":"1","key":"14","first-page":"S134","article-title":"Immunocompromised patients with pulmonary tuberculosis; a susceptible group to intestinal parasites","volume":"11","author":"A. 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