{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:49:42Z","timestamp":1787017782173,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004083","name":"Ministry of Science ICT and Future Planning","doi-asserted-by":"publisher","award":["NSN2011380"],"award-info":[{"award-number":["NSN2011380"]}],"id":[{"id":"10.13039\/501100004083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008783","name":"National Research Council of Science and Technology","doi-asserted-by":"publisher","award":["CRC21021"],"award-info":[{"award-number":["CRC21021"]}],"id":[{"id":"10.13039\/501100008783","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>\n                    Bojungikki\u2010tang (BJIT) is a traditional herbal medicine used in Korea, Japan, and China to treat gastrointestinal disorders. In this study, we aimed to investigate whether BJIT has protective effects against radiation\u2010induced intestinal injury and to predict the underlying therapeutic mechanisms and related pathways via network pharmacological analyses. BJIT was injected intraperitoneally (50\u2009mg\/kg body weight) to C\n                    <jats:sub>3<\/jats:sub>\n                    H\/HeN mice at 36 and 12\u2009h before exposure to partial abdominal irradiation (5\u2009Gy and 13\u2009Gy) to evaluate the apoptotic changes and the histological changes and variations in inflammatory cytokine mRNA levels in the jejunum, respectively. Through in silico network analysis, we predicted the mechanisms underlying BJIT\u2010mediated regulation of radiation\u2010induced intestinal injury. BJIT reduced the level of apoptosis in the jejunal crypts 12\u2009h post 5\u2010Gy irradiation. Histological assessment revealed intestinal morphological changes in irradiated mice 3.5\u2009days post 13\u2010Gy irradiation. Furthermore, BJIT decreased inflammatory cytokine levels following radiation exposure. Apoptosis, TNF, p53, VEGF, toll\u2010like receptor, PPAR, PI3K\u2010Akt, and MAPK signaling pathways, as well as inflammatory bowel disease (IBD), were found to be linked to the radioprotective effects of BJIT against intestinal injury. According to our results, BJIT exerted its potential protective effects by attenuating histopathological changes in jejunal crypts and suppressing inflammatory mediator levels. Therefore, BJIT is a potential therapeutic agent that can treat radiation\u2010induced intestinal injury and its associated symptoms.\n                  <\/jats:p>","DOI":"10.1155\/2023\/5417813","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T18:20:08Z","timestamp":1672856408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Protective Effect of Bojungikki\u2010Tang against Radiation\u2010Induced Intestinal Injury in Mice: Experimental Verification and Compound\u2010Target Prediction"],"prefix":"10.1155","volume":"2023","author":[{"given":"Sohi","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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