{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:22:42Z","timestamp":1758709362791,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sarcoma"],"published-print":{"date-parts":[[2023,3,10]]},"abstract":"<jats:p>Introduction. Surgical excisions of upper and lower extremity malignancies are increasing annually, due in part to the rising incidence of sarcomas. The purpose of this study is to compare readmissions, reoperation rate, and complications following surgical excision of soft\/connective tissue vs bone malignancies of the upper and lower extremities. Methods. The Nationwide Readmissions Database (NRD) was queried from 2016-2017 to conduct a retrospective analysis of 16,435 patients diagnosed with malignant neoplasms of the long bone (ULLB, n\u2009=\u20091,433) and soft tissue (ULST, n\u2009=\u20092,049) of the upper limb and malignant neoplasms of the long bone (LLLB, n\u2009=\u20095,422) and soft tissue (LLST, n\u2009=\u20097,531) of the lower limb. Patients who underwent surgical excision of their neoplasms were included. Binomial multivariate logistic regression was used to compare complications, nonelective readmission rates, and reoperation rates between the two groups at 30 and 90 days. Results. Average age of the ULST group was 61.88, with 36% female. Average age of the ULLB group was 44.97, with 41.90% female. Average age of the LLST group was 60.96, with 46.90% female. Average age of the LLLB group was 43.09, with 42.60% female. The ULST group had lower odds of readmission within 30 days <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mfenced open=\"(\" close=\")\" separators=\"|\">\n                           <a:mrow>\n                              <a:mi>p<\/a:mi>\n                              <a:mo>=<\/a:mo>\n                              <a:mn>0.263<\/a:mn>\n                           <\/a:mrow>\n                        <\/a:mfenced>\n                     <\/a:math>\n                  <\/jats:inline-formula>, which became significant within 90 days of surgery <jats:inline-formula>\n                     <f:math xmlns:f=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <f:mfenced open=\"(\" close=\")\" separators=\"|\">\n                           <f:mrow>\n                              <f:mi>p<\/f:mi>\n                              <f:mo>=<\/f:mo>\n                              <f:mn>0.045<\/f:mn>\n                           <\/f:mrow>\n                        <\/f:mfenced>\n                     <\/f:math>\n                  <\/jats:inline-formula>. The LLST group had significantly higher odds of infection, reoperation within 30 to 90 days of the index surgery compared to the LLLB group <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <k:mfenced open=\"(\" close=\")\" separators=\"|\">\n                           <k:mrow>\n                              <k:mi>p<\/k:mi>\n                              <k:mo>&lt;<\/k:mo>\n                              <k:mn>0.0001<\/k:mn>\n                           <\/k:mrow>\n                        <\/k:mfenced>\n                     <\/k:math>\n                  <\/jats:inline-formula>. The LLST group had significantly lower odds of readmission within 30 <jats:inline-formula>\n                     <p:math xmlns:p=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <p:mfenced open=\"(\" close=\")\" separators=\"|\">\n                           <p:mrow>\n                              <p:mi>p<\/p:mi>\n                              <p:mo>=<\/p:mo>\n                              <p:mn>0.04<\/p:mn>\n                           <\/p:mrow>\n                        <\/p:mfenced>\n                     <\/p:math>\n                  <\/jats:inline-formula> and 90 days <jats:inline-formula>\n                     <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <u:mfenced open=\"(\" close=\")\" separators=\"|\">\n                           <u:mrow>\n                              <u:mi>p<\/u:mi>\n                              <u:mo>=<\/u:mo>\n                              <u:mn>0.015<\/u:mn>\n                           <\/u:mrow>\n                        <\/u:mfenced>\n                     <\/u:math>\n                  <\/jats:inline-formula> of the index surgery. Conclusion. Patients in the ULST group had significantly lower odds of 90-day readmission compared to the ULLB group. There were also significantly lower odds of 30- and 90-day readmission in the LLST group compared to the LLLB group. However, the LLST group had significantly higher odds of infection and reoperation within 30 and 90 days compared to the LLLB group.<\/jats:p>","DOI":"10.1155\/2023\/5455719","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T22:28:10Z","timestamp":1678919290000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Postoperative Complication and Reoperation Rates Following Resection of Soft Tissue vs. Bone Malignancies Based on Anatomic Location in the Inpatient Setting"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2819-3831","authenticated-orcid":true,"given":"Alexander M.","family":"Ballatori","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7561-4590","authenticated-orcid":true,"given":"Shane","family":"Shahrestani","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8891-0353","authenticated-orcid":true,"given":"Andy","family":"Ton","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5062-7010","authenticated-orcid":true,"given":"Xiao T.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6748-5418","authenticated-orcid":true,"given":"Tarek","family":"Yamout","sequence":"additional","affiliation":[{"name":"Virginia Spine Institute, Reston, Virginia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7979-9289","authenticated-orcid":true,"given":"Brandon S.","family":"Gettleman","sequence":"additional","affiliation":[{"name":"University of South Carolina School of Medicine, Columbia, SC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1293-1702","authenticated-orcid":true,"given":"Nathanael D.","family":"Heckmann","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence R.","family":"Menendez","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0447-5762","authenticated-orcid":true,"given":"Alexander B.","family":"Christ","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Keck School of Medicine of USC, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.26809"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23685"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2020.0058"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22239"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/sla.0000000000000869"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620x.102b12.bjj-2019-1136.r3"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2019.10575"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1688101"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2019.05.041"},{"issue":"3","key":"10","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.hcl.2004.03.007","article-title":"Soft tissue sarcoma of the upper extremity","volume":"20","author":"P. 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