{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:02:17Z","timestamp":1793311337850,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2023,12,13]]},"abstract":"<jats:p>Acquired coagulopathies resulting from factor X deficiency are rare and typically associated with amyloidosis or plasma cell dyscrasia. Factor X plays a pivotal role in the coagulation cascade, converting prothrombin into thrombin and facilitating the formation of fibrinogen and thrombus. While its occurrence following common infections is extremely rare, isolated cases have been documented. We present a rare case of bleeding diathesis in a patient with community-acquired pneumonia, where prolonged activated partial thromboplastin time (aPTT) and prothrombin time (PT) led to the diagnosis of an infectious-triggered acquired circulating inhibitor targeting factor X. Prompt treatment with methylprednisolone effectively controlled the inhibitor without recurrence. This case report provides insights into the diagnostic strategies, differential algorithm, and therapeutic approaches for managing this rare coagulopathy.<\/jats:p>","DOI":"10.1155\/2023\/5510654","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T16:20:11Z","timestamp":1702484411000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Circulating Inhibitor against Factor X: A Rare Cause of Hemorrhagic Diathesis"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9391-9914","authenticated-orcid":true,"given":"P.","family":"Rossignon","sequence":"first","affiliation":[{"name":"Hematology-Oncology Department and Cardiology Department, Centre Hospitalier de Luxembourg, Luxembourg City, Luxembourg"},{"name":"Department of Internal Medicine, Erasmus University Hospital, ULB, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Grandjean","sequence":"additional","affiliation":[{"name":"Department of Clinical Biology, Department of Endocrinology and Diabetology and Department of Hematology and Oncology, Cliniques du Sud Luxembourg-Vivalia, Arlon, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Claessens","sequence":"additional","affiliation":[{"name":"Department of Clinical Biology, Department of Endocrinology and Diabetology and Department of Hematology and Oncology, Cliniques du Sud Luxembourg-Vivalia, Arlon, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Weynants","sequence":"additional","affiliation":[{"name":"Department of Clinical Biology, Department of Endocrinology and Diabetology and Department of Hematology and Oncology, Cliniques du Sud Luxembourg-Vivalia, Arlon, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","first-page":"1858","article-title":"Laboratory evaluation of hemostatic and thrombotic disorders","volume-title":"Hematology: Basic Principles and Practice","author":"A. H. Schmaier","year":"2013","edition":"6th"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1997.00106.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2015-0978"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2021-0123-oa"},{"key":"5","first-page":"448","article-title":"Investigation of a thrombotic tendency","volume-title":"Dacie and Lewis Practical Haematology","author":"M. Laffan","year":"2011","edition":"6th"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1159\/000342115"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02773.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1055\/a-1496-8527"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.4142-19"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14711"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.31473"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3390\/hematolrep15020032"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/96.2.196"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-143586"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-010-0529-6"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2008.03.005"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1096-8652(199803)57:3<245::aid-ajh13>3.0.co;2-9"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21105"},{"issue":"1","key":"19","first-page":"29","article-title":"Isolated acquired fx deficiency: a case report","volume":"17","author":"M. Ayl\u0131","year":"2000","journal-title":"Turkish Journal of Haematology"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2023\/5510654.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2023\/5510654.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2023\/5510654.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T16:20:15Z","timestamp":1702484415000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crihem\/2023\/5510654\/"}},"subtitle":[],"editor":[{"given":"H\u00e5kon","family":"Reikvam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,12,13]]},"references-count":19,"alternative-id":["5510654","5510654"],"URL":"https:\/\/doi.org\/10.1155\/2023\/5510654","relation":{},"ISSN":["2090-6579","2090-6560"],"issn-type":[{"value":"2090-6579","type":"electronic"},{"value":"2090-6560","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12,13]]}}}