{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T13:01:28Z","timestamp":1793624488495,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":262,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Malaria is a global public health concern, mainly occurring in sub\u2010Saharan Africa. Children infected with malaria are more likely to develop severe disease, which can be fatal. During COVID\u201019 in 2020, diagnosing and treating malaria became difficult. We analyzed the clinical characteristics and laboratory indicators of children with severe malaria in Benin to provide important information for designing effective prevention and treatment strategies to manage pediatric cases. <jats:italic>Methods<\/jats:italic>. Clinical characteristics of pediatric patients with severe malaria admitted to two hospitals in Benin (Central Hospital of Lokossa and Regional Hospital of Natitingou, located \u223c650\u2009kilometers apart) were collected from January to December 2020. Patients were grouped according to age (group A: 4\u201312\u2009months old, group B: 13\u201336\u2009months old, and group C: 37\u201360\u2009months old), and clinical and laboratory indicators were compared. The incidences of severe pediatric malaria in both hospitals in 2020 were calculated. Inclusion, exclusion, and blood transfusion criteria were identified. <jats:italic>Results<\/jats:italic>. We analyzed 236 pediatric cases. The main clinical symptoms among all patients were severe anemia, vomiting, prostration, poor appetite, dysphoria, and dyspnea. Over 50% of patients in group A experienced vomiting and severe anemia. Most patients in group B had severe anemia and prostration. Delirium affected significantly more patients in group C than in groups A and B. In group C, the hemoglobin and hematocrit levels were significantly higher (<jats:italic>p<\/jats:italic> &lt; 0.05), and the leukocyte count was significantly lower (<jats:italic>p<\/jats:italic> &lt; 0.01) than in groups A and B. Parasitemia was significantly higher in group C than in group A (<jats:italic>p<\/jats:italic> &lt; 0.01). Twelve deaths occurred. <jats:italic>Conclusions<\/jats:italic>. Severe pediatric malaria is seasonal in Benin. The situation in children under 5\u2009years old is poor. The main problems are severe disease conditions and high fatality rates. Effective approaches such as prevention and early and appropriate treatment are necessary to reduce the malaria burden in pediatric patients.<\/jats:p>","DOI":"10.1155\/2023\/5516408","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T16:20:06Z","timestamp":1695226806000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical and Biological Characteristics of Severe Malaria in Children under 5\u2009Years Old in Benin"],"prefix":"10.1155","volume":"2023","author":[{"given":"Xiao","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kora Chabi","family":"Youssaou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8160-9999","authenticated-orcid":false,"given":"Shuping","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0718-4992","authenticated-orcid":false,"given":"Yujing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.17795\/iji-31548"},{"key":"e_1_2_13_2_2","volume-title":"World Malaria Report 2021","author":"Who","year":"2021"},{"key":"e_1_2_13_3_2","unstructured":"USAID Ethiopia malaria operational plan 2020 https:\/\/www.pmi.gov\/."},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/524888"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir180"},{"key":"e_1_2_13_6_2","volume-title":"World Malaria Report 2018","author":"Who","year":"2018"},{"key":"e_1_2_13_7_2","first-page":"19","article-title":"Progress and challenges of global malaria elimination","volume":"31","author":"Zhu G. 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