{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T16:38:56Z","timestamp":1773333536719,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002412","name":"Xi\u2019an Jiaotong University","doi-asserted-by":"publisher","award":["2021ZYTS-29"],"award-info":[{"award-number":["2021ZYTS-29"]}],"id":[{"id":"10.13039\/501100002412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002412","name":"Xi\u2019an Jiaotong University","doi-asserted-by":"publisher","award":["2022SF-350"],"award-info":[{"award-number":["2022SF-350"]}],"id":[{"id":"10.13039\/501100002412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2021ZYTS-29"],"award-info":[{"award-number":["2021ZYTS-29"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["2022SF-350"],"award-info":[{"award-number":["2022SF-350"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2023,9,5]]},"abstract":"<jats:p>Backgrounds. Serum total bilirubin (STB) is recently more regarded as an antioxidant with vascular protective effects. However, we noticed that elevated STB appeared in unstable angina pectoris (UAP) patients with diffused coronary lesions. We aimed to explore STB\u2019s roles in UAP patients, which have not been reported by articles. Methods and Results. 1120 UAP patients were retrospectively screened, and 296 patients were finally enrolled. They were grouped by Canadian Cardiovascular Society (CCS) angina grades. The synergy between PCI with TAXUS stent and cardiac surgery score (SYNTAX score) and corrected thrombolysis in myocardial infarction flow count (CTFC) were adopted to profile coronary features. The results showed that STB, mean platelet volume (MPV), hs-CRP, fasting blood glucose (FBG), red blood cell width (RDW), and CTFC elevated significantly in the CCS high-risk group. STB (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>B<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.59<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>, 95% CI: 0.39-0.74, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.01<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>) and MPV (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>B<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.86<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>, 95% CI: 0.42-1.31, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.01<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>) could indicate SYNTAX score changes for these patients. STB (\u226521.7\u2009\u03bcmol\/L) could even indicate a coronary slow flow condition (AUC: 0.88, 95% CI: 0.84-0.93, <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.01<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>). Moreover, UAP patients with elevated STB had a lower event-free survival rate by the Kaplan-Meier curve. STB \u226521.7\u2009\u03bcmol\/L could reflect a poor coronary flow status and indicate 1-year poor outcomes for these patients (HR: 2.01, 95% CI: 1.06-3.84, <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.01<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>). Conclusion. Elevated STB in UAP patients has a close relationship with changes in SYNTAX score. STB (over 21.7\u2009\u03bcmol\/L) could even indicate a coronary slow flow condition and poor outcomes for the UAP patients.<\/jats:p>","DOI":"10.1155\/2023\/5532917","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T17:50:24Z","timestamp":1693936224000},"page":"1-9","source":"Crossref","is-referenced-by-count":5,"title":["Elevated Serum Total Bilirubin Might Indicate Poor Coronary Conditions for Unstable Angina Pectoris Patients beyond as a Cardiovascular Protector"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4502-7595","authenticated-orcid":true,"given":"Qi","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Cardiology, First Affiliated Hospital of Xi\u2019an Jiaotong University, No. 277 Yanta Rd, Shaanxi, Xi\u2019an 710061, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0391-1443","authenticated-orcid":true,"given":"Yongjian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, First Affiliated Hospital of Xi\u2019an Jiaotong University, No. 277 Yanta Rd, Shaanxi, Xi\u2019an 710061, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5210-5430","authenticated-orcid":true,"given":"Jin","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Medical Insurance, Xi\u2019an Affiliated Hospital of the Shaanxi University of Chinese Medicine, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11853"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-014-6511-3"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2019.02.011"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.02.051"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.06.021"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.5551\/jat.RV17035"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2019.06.003"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017544"},{"issue":"2","key":"9","first-page":"219","article-title":"The SYNTAX score: an angiographic tool grading the complexity of coronary artery disease","volume":"1","author":"G. 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