{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:54:09Z","timestamp":1761710049411,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Ophthalmological Medicine"],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:p>Background. This study is aimed at exploring a case of choroidal Langerhans cell histiocytosis (LCH) successfully treated with systemic corticosteroid and immunosuppressant. Case presentation. A 24-year-old man with known multisystem LCH developed loss of vision, ocular pain, conjunctival injection, panuveitis, and a ciliochoroidal mass. After receiving an intravenous methylprednisolone pulse, oral high-dose corticosteroids, and methotrexate, the mass resolved quickly and completely without flare-ups during 6 months of follow-up. Conclusions. Intraocular involvement of LCH is rare and can present with or without a history of multisystemic disease. The diagnosis is challenging, and the standard treatment is not established. Systemic anti-inflammatory and immunosuppressive therapy could be an effective treatment, as the LCH itself contains an essential element of inflammation and the symptoms may be mainly inflammatory.<\/jats:p>","DOI":"10.1155\/2023\/5543131","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T17:20:09Z","timestamp":1693588809000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Langerhans Cell Histiocytosis of the Uvea with a Ciliochoroidal Mass: A Case Report of Management with Systemic Therapy"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9423-9650","authenticated-orcid":true,"given":"Fariba","family":"Ghassemi","sequence":"first","affiliation":[{"name":"Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Retina & Vitreous Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2277-398X","authenticated-orcid":true,"given":"Hamid","family":"Riazi-Esfahani","sequence":"additional","affiliation":[{"name":"Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Retina & Vitreous Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2058-9225","authenticated-orcid":true,"given":"Nazanin","family":"Ebrahimiadib","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Florida, Gainesville, FL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1030-3649","authenticated-orcid":true,"given":"Abdulrahim","family":"Amini","sequence":"additional","affiliation":[{"name":"Retina & Vitreous Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Ophthalmology, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3614-202X","authenticated-orcid":true,"given":"Zahra","family":"Mahdizad","sequence":"additional","affiliation":[{"name":"Retina & Vitreous Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.05.059"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199702)28:2<92::AID-MPO2>3.0.CO;2-N"},{"key":"3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2147\/IMCRJ.S162038","article-title":"Langerhans cell histiocytosis with hemorrhagic uveitis and exudative retinal detachment","volume":"11","author":"R. 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