{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:29:22Z","timestamp":1754108962811,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T00:00:00Z","timestamp":1703548800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Interventional Cardiology"],"published-print":{"date-parts":[[2023,12,26]]},"abstract":"<jats:p>Background. Dual antiplatelet therapy with a P2Y12 inhibitor (e.g., clopidogrel and ticagrelor) and aspirin is recommended for at least one year after percutaneous coronary intervention (PCI) to prevent further myocardial infarction and stent thrombosis as the major adverse effects of PCI. Methods. This randomized clinical trial was conducted from October 2022 to March 2023. Patients who had undergone elective PCI were included in the study. Patients were randomized into two different groups. One group took ASA 80\u2009mg and clopidogrel 75\u2009mg once daily, while the other took ASA 80\u2009mg once daily and ticagrelor 90\u2009mg twice daily. After six months of close follow-up, patients were asked to score their dyspnea on a 10-point Likert scale. They were also asked about dyspnea on exertion, paroxysmal nocturnal dyspnea (PND), bleeding, and the occurrence of major adverse cardiovascular events (MACEs). Results. 223 patients were allocated to the clopidogrel group and 214 to the ticagrelor group. In the ticagrelor group, 95 patients (44.3%) reported dyspnea at rest, compared with only 44 patients (19.7%) in the clopidogrel group (<jats:inline-formula><a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><a:mi>P<\/a:mi><\/a:math><\/jats:inline-formula>\u2009&lt;\u20090.001). MACEs occurred in 7 patients (2.8%) in the ticagrelor group, compared with 16 (7.6%) in the clopidogrel group (<jats:inline-formula><c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><c:mi>P<\/c:mi><\/c:math><\/jats:inline-formula>\u2009=\u20090.031). Eight patients (3.8%) reported bleeding with ticagrelor, as did seven (3.2%) with clopidogrel (<jats:inline-formula><e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><e:mi>P<\/e:mi><\/e:math><\/jats:inline-formula>\u2009=\u20090.799). Conclusions. New-onset dyspnea was recorded more frequently with ticagrelor than clopidogrel, yet fewer MACEs occurred with ticagrelor (ClinicalTrials.gov number: NCT05858918).<\/jats:p>","DOI":"10.1155\/2023\/5544440","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T20:05:06Z","timestamp":1703621106000},"page":"1-8","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Ticagrelor and Clopidogrel in Elective Coronary Stenting: A Double Blind Randomized Clinical Trial"],"prefix":"10.1155","volume":"2023","author":[{"given":"Mohammadjavad","family":"Mehdizadeh Parizi","sequence":"first","affiliation":[{"name":"Professor Kojuri Cardiology Clinic, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Golchin Vafa","sequence":"additional","affiliation":[{"name":"Professor Kojuri Cardiology Clinic, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Professor Kojuri Cardiology Clinic, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Heydarzade","sequence":"additional","affiliation":[{"name":"Professor Kojuri Cardiology Clinic, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrdad","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Professor Kojuri Cardiology Clinic, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin","family":"Khademolhossseini","sequence":"additional","affiliation":[{"name":"Professor Kojuri Cardiology Clinic, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhang","family":"Amiri","sequence":"additional","affiliation":[{"name":"Professor Kojuri Cardiology Clinic, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soroush","family":"Khoshnood Mansorkhani","sequence":"additional","affiliation":[{"name":"Professor Kojuri Cardiology Clinic, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Tavan","sequence":"additional","affiliation":[{"name":"Professor Kojuri Cardiology Clinic, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazanin","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Professor Kojuri Cardiology Clinic, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Montaseri","sequence":"additional","affiliation":[{"name":"Professor Kojuri Cardiology Clinic, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4397-1539","authenticated-orcid":true,"given":"Seyed Ali","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Professor Kojuri Cardiology Clinic, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8909-897X","authenticated-orcid":true,"given":"Javad","family":"Kojuri","sequence":"additional","affiliation":[{"name":"Professor Kojuri Cardiology Clinic, Shiraz, Iran"},{"name":"Cardiology Department, Shiraz University of Medical Sciences, Shiraz, Iran"},{"name":"Clinical Education Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61752-3"},{"volume-title":"Cardiovascular Disease","year":"2020","author":"E. 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