{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:48:55Z","timestamp":1790743735562,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"KIKA\/ODAS","award":["171 \u201cDCOG LATER Program\u201d"],"award-info":[{"award-number":["171 \u201cDCOG LATER Program\u201d"]}]},{"name":"KIKA\/ODAS","award":["KUN 2014-6985"],"award-info":[{"award-number":["KUN 2014-6985"]}]},{"DOI":"10.13039\/501100004622","name":"Dutch Cancer Society","doi-asserted-by":"crossref","award":["171 \u201cDCOG LATER Program\u201d"],"award-info":[{"award-number":["171 \u201cDCOG LATER Program\u201d"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004622","name":"Dutch Cancer Society","doi-asserted-by":"crossref","award":["KUN 2014-6985"],"award-info":[{"award-number":["KUN 2014-6985"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2023,10,20]]},"abstract":"<jats:p>Background. Childhood cancer survivors (CCS) who received radiotherapy involving the spleen or total body irradiation (TBI) might be at risk for splenic dysfunction. A comprehensive screening test for examining splenic dysfunction is lacking. Objective. We investigated whether IgM memory B-cells could be used to assess splenic dysfunction in CCS who received a splenectomy, radiotherapy involving the spleen, or TBI. Methods. All CCS were enrolled from the DCCSS-LATER cohort. We analyzed differences in IgM memory B-cells and Howell\u2013Jolly bodies (HJB) in CCS who had a splenectomy (n\u2009=\u20099), received radiotherapy involving the spleen (n\u2009=\u200936), or TBI (n\u2009=\u200915). IgM memory B-cells\u2009&lt;\u20099\u2009cells\/\u00b5L was defined as abnormal. Results. We observed a higher median number of IgM memory B-cells in CCS who received radiotherapy involving the spleen (31\u2009cells\/\u00b5L, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.06<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) or TBI (55\u2009cells\/\u00b5L, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                     <\/c:math>\n                  <\/jats:inline-formula>\u2009=\u20090.03) compared to CCS who received splenectomy (20\u2009cells\/\u00b5L). However, only two CCS had IgM memory B-cells below the lower limit of normal. No difference in IgM memory B-cells was observed between CCS with HJB present and absent (35\u2009cells\/\u00b5L vs. 44\u2009cells\/\u00b5L). Conclusion. Although the number of IgM memory B-cells differed between splenectomized CCS and CCS who received radiotherapy involving the spleen or TBI, only two CCS showed abnormal values. Therefore, this assessment cannot be used to screen for splenic dysfunction.<\/jats:p>","DOI":"10.1155\/2023\/5863995","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T16:50:20Z","timestamp":1697820620000},"page":"1-8","source":"Crossref","is-referenced-by-count":2,"title":["The Value of IgM Memory B-Cells in the Assessment of Splenic Function in Childhood Cancer Survivors at Risk for Splenic Dysfunction: A DCCSS-LATER Study"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9242-5676","authenticated-orcid":true,"given":"Bente M.","family":"Houtman","sequence":"first","affiliation":[{"name":"Department of Hematology, Center of Expertise for Cancer Survivorship, Radboud University Medical Center, Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Walraven","sequence":"additional","affiliation":[{"name":"Department for Health Evidence, Radboud University Medical Center, Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"de Grouw","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine\u2014Radboudumc Laboratory of Diagnostics, Radboud University Medical Center, Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W. M.","family":"van der Maazen","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Radboud University Medical Center, Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leontien C. M.","family":"Kremer","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, Netherlands"},{"name":"Wilhelmina Children\u2019s Hospital, University Medical Center, Utrecht, Netherlands"},{"name":"Department of Pediatric Oncology, Emma Children\u2019s Hospital, University of Amsterdam, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline","family":"van Dulmen-den Broeder","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology\/Hematology, Amsterdam University Medical Center, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marry M.","family":"van den Heuvel-Eibrink","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, Netherlands"},{"name":"Wilhelmina Children\u2019s Hospital, University Medical Center, Utrecht, Netherlands"},{"name":"Department of Pediatric Oncology, Sophia Children\u2019s Hospital, Erasmus Medical Center, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim J. E.","family":"Tissing","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, Netherlands"},{"name":"Department of Pediatric Oncology\/Hematology, Beatrix Children\u2019s Hospital\/University of Groningen\/University Medical Center Groningen, Groningen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorine","family":"Bresters","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena J. H.","family":"van der Pal","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrica C. H.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Sophia Children\u2019s Hospital, Erasmus Medical Center, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marloes","family":"Louwerens","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Leiden University Medical Center, Leiden, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margriet","family":"van der Heiden-van der Loo","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian J. C.","family":"Neggers","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, Netherlands"},{"name":"Department of Medicine, Section Endocrinology, Erasmus Medical Center, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert O.","family":"Janssens","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, Netherlands"},{"name":"Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M. A.","family":"Blijlevens","sequence":"additional","affiliation":[{"name":"Department of Hematology, Radboud University Medical Center, Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annechien J. 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