{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T10:38:36Z","timestamp":1789123116063,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":39,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015310","name":"Natural Science Foundation of Xinjiang","doi-asserted-by":"publisher","award":["2021D01A185"],"award-info":[{"award-number":["2021D01A185"]}],"id":[{"id":"10.13039\/501100015310","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Evidence\u2010based research methods were applied to assess the efficacy of faecal microbiota transplantation (FMT) for the treatment of autism in children. <jats:italic>Methods<\/jats:italic>. We searched the Chinese Biomedical Literature, CNKI, Wanfang, PubMed, Embase, Web of Science, and the Cochrane Library databases to collect randomised controlled trials on faecal microbiota transplantation for the treatment of autism in children. The search included studies published from the creation of the respective database to 5 April 2022. Literature screening, data extraction, and quality evaluation were implemented by three investigators according to the inclusion and exclusion criteria. The meta\u2010analysis was performed using the RevMan 5.1 software. <jats:italic>Results<\/jats:italic>. Nine studies with population\u2010based subjects and four studies with animal\u2010based subjects were included. Five papers were screened for the meta\u2010analysis. The results showed that FMT markedly reduced Autism Behaviour Checklist (ABC) scores in children with autism spectrum disorder (weighted mean difference (WMD)\u2009=\u2009\u221214.96; 95% confidence intervals (CI), \u221221.68 to \u22128.24; <jats:italic>P<\/jats:italic> &lt; 0.001; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%). FMT also reduced Childhood Autism Rating Scale (CARS) scores (WMD\u2009=\u2009\u22126.95; 95% CI, \u22128.76 to \u22125.14; <jats:italic>P<\/jats:italic> &lt; 0.001; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200928.1%). <jats:italic>Conclusion<\/jats:italic>. Our results indicate that FMT can benefit children with autism by reducing ABC and CARS scores, but more high\u2010quality studies are needed to verify these results.<\/jats:p>","DOI":"10.1155\/2023\/5993628","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T20:05:09Z","timestamp":1675973109000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy of Faecal Microbiota Transplantation for the Treatment of Autism in Children: Meta\u2010Analysis of Randomised Controlled 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