{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:50:48Z","timestamp":1787928648390,"version":"build-2784847793"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":291,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100022253","name":"Pan African University","doi-asserted-by":"publisher","award":["AU\/003\/2018\/2019"],"award-info":[{"award-number":["AU\/003\/2018\/2019"]}],"id":[{"id":"10.13039\/501100022253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009402","name":"Mekelle University","doi-asserted-by":"publisher","award":["RF\/003\/2018\/2019"],"award-info":[{"award-number":["RF\/003\/2018\/2019"]}],"id":[{"id":"10.13039\/501100009402","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. This study was aimed at determining the antioxidant, anti\u2010quorum sensing, and <jats:italic>in vitro<\/jats:italic> cytotoxic activities of five wild mushroom extracts. <jats:italic>Methods<\/jats:italic>. Wild mushrooms of <jats:italic>Auricularia auricula-judae<\/jats:italic>, <jats:italic>Termitomyces umkowaani<\/jats:italic>, <jats:italic>Trametes elegans<\/jats:italic>, <jats:italic>Trametes versicolor,<\/jats:italic> and <jats:italic>Microporus xanthopus<\/jats:italic> were collected from Arabuko\u2010Sokoke and Kakamega National Forests, in Kenya. Specimens were identified and extracted using chloroform (CHL), 70% ethanol (Eth), and hot water (HW) solvents. Antioxidant and cytotoxic activities of the extracts were determined using 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl (DPPH) and Vero cell lines, respectively, while anti\u2010quorum sensing activities were tested against <jats:italic>Chromobacterium violaceum<\/jats:italic>. All data were compared using relevant descriptive and inferential statistics at a significance level of <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05. <jats:italic>Results<\/jats:italic>. A total of 35 wild mushrooms were collected, identified, and classified into 14 genera. Among screened mycochemicals, fatty acids, flavonoids, polyphenols, and saponins were detected at higher concentrations. The highest free radical scavenging activities of <jats:italic>A. auricula-judae<\/jats:italic>, <jats:italic>T. umkowaani<\/jats:italic>, <jats:italic>T. elegans<\/jats:italic>, and <jats:italic>T. versicolor<\/jats:italic> were observed in 70% Eth extract with the percentage values of 76.40\u2009\u00b1\u20090.12%, 68.40\u2009\u00b1\u20090.01%, 62.40\u2009\u00b1\u20090.07%, and 66.40\u2009\u00b1\u20090.04%, respectively, whereas the HW extract of <jats:italic>Microporus xanthopus<\/jats:italic> showed free radical scavenging activity at 65.90\u2009\u00b1\u20090.02%. None of the extracts, at the tested concentrations (up to 1000\u2009<jats:italic>\u00b5<\/jats:italic>g\/mL), had shown cytotoxic activity against the Vero cell line. The HW extract of <jats:italic>T. umkowaani<\/jats:italic> and the 70% Eth extract of <jats:italic>T. versicolor<\/jats:italic> showed a statistically significant difference in the inhibitory activity of violacein production against <jats:italic>C. violaceum<\/jats:italic> at the concentration of 200\u2009<jats:italic>\u00b5<\/jats:italic>g\/mL. <jats:italic>Conclusions<\/jats:italic>. The antioxidant activity of wild mushrooms can help to tackle the diseases caused by free radicals. The anti\u2010quorum sensing potential of wild mushrooms could also provide future alternatives to conventional drug therapies cost\u2010effectively. Further detailed chemistry of the bioactive compounds and their possible mechanisms of action responsible for the observed antioxidant and anti\u2010quorum sensing activities are needed.<\/jats:p>","DOI":"10.1155\/2023\/6141646","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T19:50:09Z","timestamp":1697745009000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Wild Mushrooms: Potential Natural Sources of Antioxidant and Anti\u2010Quorum Sensing Bioactive Compounds for Medical Applications"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2697-4818","authenticated-orcid":false,"given":"Gebreselema","family":"Gebreyohannes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3602-1578","authenticated-orcid":false,"given":"Desta Berhe","family":"Sbhatu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3423-4484","authenticated-orcid":false,"given":"Andrew","family":"Nyerere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5635-3871","authenticated-orcid":false,"given":"Christine","family":"Bii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1222-5584","authenticated-orcid":false,"given":"Abrha Gebreselema","family":"Gebrehiwot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.4103\/2319-4170.138318"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3073906"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.13057\/biodiv\/d221102"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.5539\/jfr.v2n3p137"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.925387"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics3030022"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/tcr.20074"},{"key":"e_1_2_13_8_2","first-page":"1","article-title":"Applied sciences antimicrobial efficacy of edible mushroom extracts: assessment of fungal resistance","volume":"12","author":"Kim J. 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