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Recently, an increasing number of studies have demonstrated that inflammatory mediators play a crucial role in IDD, and they are being explored as potential treatment targets for IDD and associated disorders. For example, interleukins (IL), tumour necrosis factor-\u03b1 (TNF-\u03b1), chemokines, and inflammasomes have all been linked to the pathophysiology of IDD. These inflammatory mediators are found in high concentrations in intervertebral disc (IVD) tissues and cells and are associated with the severity of LBP and IDD. It is feasible to reduce the production of these proinflammatory mediators and develop a novel therapy for IDD, which will be a hotspot of future research. In this review, the effects of inflammatory mediators in IDD were described.<\/jats:p>","DOI":"10.1155\/2023\/6210885","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T22:05:09Z","timestamp":1681769109000},"page":"1-19","source":"Crossref","is-referenced-by-count":54,"title":["Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0112-1678","authenticated-orcid":true,"given":"Zhangfu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5300-1283","authenticated-orcid":true,"given":"Honghao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7206-325X","authenticated-orcid":true,"given":"Yong","family":"Hai","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5553-5211","authenticated-orcid":true,"given":"Yunzhong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.F.00019"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200109010-00011"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-006-0294-6"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-4090-1_8"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-008-0743-5"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.03.028"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14488"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2017.01.001"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2015.02.001"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2014.07.013"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2007.07.392"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2015.09.001"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000231761.73859.2c"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1186\/ar4353"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-019-0821-x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000146101.53784.b1"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.08.014"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000001982"},{"issue":"1","key":"19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrrheum.2013.160","article-title":"Role of cytokines in intervertebral disc degeneration: pain and disc content","volume":"10","author":"M. 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