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Both high\u2010fat diet (HFD) and 4\u2010nonylphenol (4\u2010NP) could affect fat formation in adipose tissue individually. We investigated whether HFD promote abnormal adipose tissue formation caused by early exposure to 4\u2010NP in life and preliminarily explore the possible mechanisms involved. <jats:italic>Methods<\/jats:italic>. The first\u2010generation rats were treated with HFD on postnatal day after pregnant rats exposure to 5\u2009ug\/kg\/day 4\u2010NP. Then, the second generation rats started to only receive normal diet without 4\u2010NP or HFD. We analyzed organ coefficient and histopathology of fat tissues, biochemical index, and gene level involved in lipid metabolism in female offspring rats. <jats:italic>Results<\/jats:italic>. HFD and 4\u2010NP interaction synergistically increased birth weight, body weight, and organ coefficients of adipose tissue in offspring female rats. HFD accelerately aggravated abnormal lipid metabolism and increased the adipocyte mean areas around the uterus of the offspring female rats induced by prenatal exposure to 4\u2010NP. HFD also facilitate the regulation of gene expression involved lipid metabolism in offspring female rats induced by perinatal exposure to 4\u2010NP, even passed on to the second generation of female rats. Moreover, HFD and 4\u2010NP interaction synergistically declined the gene and protein expression of estrogen receptor (ER) in the adipose tissue of second\u2010generation female rats. <jats:italic>Conclusion<\/jats:italic>. HFD and 4\u2010NP synergistically regulate the expression of lipid metabolism genes in adipose tissue of F2 female rats and promote adipose tissue generation, leading to obesity in offspring rats, which is closely related to low expression of ER. Therefore, ER genes and proteins may be involved in the synergistic effect of HFD and 4\u2010NP.<\/jats:p>","DOI":"10.1155\/2023\/6540585","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T19:09:06Z","timestamp":1687547346000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["High\u2010Fat Diet Promotes Adipogenesis in Offspring Female Rats Induced by Perinatal Exposure to 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