{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:25:29Z","timestamp":1787682329832,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007119","name":"Yasuj University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007119","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Pharmacological and Pharmaceutical Sciences"],"published-print":{"date-parts":[[2023,8,14]]},"abstract":"<jats:p>Objective. The prevalence of kidney stones and their complications is high. The review of the literature showed the therapeutic effects of Alhagi maurorum extract on urinary tract stones. This study reviewed the Alhagi plant\u2019s hydroalcholic extract\u2019s effect on eliminating kidney and ureteral stones compared to hydrochlorothiazide. Materials and Methods. In this randomized prospective study, from March 2019 to September 2021, 80 patients over 18\u2009years of age with kidney stones in the upper ureter with a size of 4\u201310\u2009mm were divided into two groups based on the block random allocation method. The first group received hydrochlorothiazide tablets (50\u2009mg), and the second group received 1\u2009gram\/day of the hydroalcholic areal extract of Alhagi maurorum in a two-divided capsule. The mean size and number of stones, renal function tests, and side effects were checked and compared in both groups before and after the study. Results. Mean age, sex, serum urea level (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.351<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>), serum creatinine (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.393<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>), stone size (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0178<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>), and the number of stones (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.052<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>) before intervention were similar. After intervention, the size and number of stones diminished, up to 70% in both groups. However, there was not a statistically significant difference between the two groups. Conclusion. The study showed that Alhagi maurorum is as effective as hydrochlorothiazide in treatment of kidney and ureteral stones with no significant complications and is promising.<\/jats:p>","DOI":"10.1155\/2023\/6624981","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T22:50:18Z","timestamp":1692053418000},"page":"1-5","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of the Effect of Hydroalcholic Extract of Alhagi maurorum and Hydrochlorothiazide on Excretion of 4\u201310\u2009mm Kidney and Ureteral Stones in Adults: A Randomized Prospective Study"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8481-9205","authenticated-orcid":true,"given":"Sadrollah","family":"Mehrabi","sequence":"first","affiliation":[{"name":"Clinical Research Development Unit, Shahid Beheshti Hospital, Yasuj University of Medical Sciences, Yasuj, Iran"},{"name":"Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6549-7773","authenticated-orcid":true,"given":"Parisa","family":"Beigi","sequence":"additional","affiliation":[{"name":"Clinical Research Development Unit, Shahid Beheshti Hospital, Yasuj University of Medical Sciences, Yasuj, Iran"},{"name":"Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5999-3316","authenticated-orcid":true,"given":"Zeinab","family":"Salehpour","sequence":"additional","affiliation":[{"name":"Clinical Research Development Unit, Shahid Beheshti Hospital, Yasuj University of Medical Sciences, Yasuj, Iran"},{"name":"Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1159\/000049803"},{"issue":"5","key":"2","first-page":"247","article-title":"Unani concept of nephrolithiasis (hisat-e-kulyah) and its management: an overview","volume":"2","author":"M. S. Khan","year":"2016","journal-title":"World Journal of Pharmaceutical and Medical Research"},{"issue":"4","key":"3","first-page":"305","article-title":"Nephrolithiasis: a consequence of renal epithelial cell exposure to oxalate and calcium oxalate crystals","volume":"4","author":"S. Khan","year":"2000","journal-title":"Molecular Urology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.15171\/jrip.2016.27"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.05.006"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1590\/s0004-27302006000400027"},{"issue":"2","key":"7","first-page":"129","article-title":"Effect of hydrophilic extract of Alhagi maurorum on ethylene glycol-induced renal stone in male wistar rats","volume":"17","author":"A. Shafaeifar","year":"2012","journal-title":"Armaghane Danesh"},{"issue":"3","key":"8","first-page":"592","article-title":"Antiurolithiatic plants of family Fabaceae: a memoir of mechanism of action, therapeutic spectrum, formulations with doses","volume":"6","author":"S. Ahmed","year":"2017","journal-title":"Journal of Pharmacognosy and Phytochemistry"},{"key":"9","article-title":"Traditional uses, phytochemistry, pharmacological properties of plant Alhagi maurorum (medik.): A Review","author":"P. Suthar","year":"2016"},{"issue":"1","key":"10","first-page":"56","article-title":"The effect of Alhagi Pseudalhagi distillate on ureteral stone expulsion","volume":"13","author":"A. Cyrus","year":"2010","journal-title":"Journal of Arak University of Medical Sciences"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1978.58"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02191.x"},{"issue":"2","key":"13","first-page":"68","article-title":"The effectiveness of hydrochlorothiazide on preventing recurrent urinary tract infection in idiopathic hypercalciuric children","volume":"9","author":"P. Yosefi","year":"2006","journal-title":"Journal of Arak University of Medical Sciences"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-010-9824-6"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2009.12.007"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscs.2010.02.015"},{"issue":"2","key":"17","first-page":"47","article-title":"Alhagi pseudalhagi: a review of its phyto-chemistry, pharmacology, folklore claims and Ayurvedic studies","volume":"2","author":"B. Srivastava","year":"2014","journal-title":"International Journal of Herbal Medicine"},{"key":"18","volume-title":"Chemical Study of The Therapeutic Effect of Alhaji Maurorum Aqueous Extract on Formtion and Dissolution of Calcium Oxalate Kindney Calculi","author":"H. Mostaanzadeh","year":"2017"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7796.134261"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1590\/1519-6984.259100"}],"container-title":["Advances in Pharmacological and Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/aps\/2023\/6624981.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/aps\/2023\/6624981.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/aps\/2023\/6624981.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T22:50:28Z","timestamp":1692053428000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/aps\/2023\/6624981\/"}},"subtitle":[],"editor":[{"given":"Nizar","family":"Tlili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,8,14]]},"references-count":20,"alternative-id":["6624981","6624981"],"URL":"https:\/\/doi.org\/10.1155\/2023\/6624981","relation":{},"ISSN":["2633-4690","2633-4682"],"issn-type":[{"value":"2633-4690","type":"electronic"},{"value":"2633-4682","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8,14]]}}}