{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:06:26Z","timestamp":1791975986206,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013278","name":"EU Joint Programme \u2013 Neurodegenerative Disease Research","doi-asserted-by":"publisher","award":["CLaSP\/JPND HC-559-002"],"award-info":[{"award-number":["CLaSP\/JPND HC-559-002"]}],"id":[{"id":"10.13039\/100013278","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["CLaSP\/JPND HC-559-002"],"award-info":[{"award-number":["CLaSP\/JPND HC-559-002"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008444","name":"Parkinsonfonden","doi-asserted-by":"publisher","award":["CLaSP\/JPND HC-559-002"],"award-info":[{"award-number":["CLaSP\/JPND HC-559-002"]}],"id":[{"id":"10.13039\/100008444","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sk\u00e5ne Health Care Region","award":["CLaSP\/JPND HC-559-002"],"award-info":[{"award-number":["CLaSP\/JPND HC-559-002"]}]},{"DOI":"10.13039\/501100003252","name":"Lunds Universitet","doi-asserted-by":"publisher","award":["CLaSP\/JPND HC-559-002"],"award-info":[{"award-number":["CLaSP\/JPND HC-559-002"]}],"id":[{"id":"10.13039\/501100003252","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Parkinson Academy","award":["CLaSP\/JPND HC-559-002"],"award-info":[{"award-number":["CLaSP\/JPND HC-559-002"]}]},{"DOI":"10.13039\/501100006075","name":"Greta och Johan Kocks stiftelser","doi-asserted-by":"publisher","award":["CLaSP\/JPND HC-559-002"],"award-info":[{"award-number":["CLaSP\/JPND HC-559-002"]}],"id":[{"id":"10.13039\/501100006075","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hardebo Foundation","award":["CLaSP\/JPND HC-559-002"],"award-info":[{"award-number":["CLaSP\/JPND HC-559-002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Parkinson's Disease"],"published-print":{"date-parts":[[2023,10,10]]},"abstract":"<jats:p>Background. National as well as international Parkinson\u2019s disease (PD) treatment guidelines are available to guide clinicians. Previous research has shown that nonmotor symptoms (NMS) are pronounced in late-stage PD and has suggested that current treatment is insufficient and could be improved. Objectives. The aim of this study was to investigate to which degree the national and international treatment guidelines are followed in the treatment of NMS in late-stage PD. Methods. This Swedish cohort was part of the Care of Late-Stage Parkinsonism (CLaSP) study. Late-stage PD was defined as Hoehn and Yahr stages IV-V in \u201con\u201d and\/or \u226450% on the Schwab and England Activities of Daily Living (ADL) scale. NMS were assessed with the NMS scale (NMSS), cognition with the Mini-Mental State Examination (MMSE), and depressive symptoms with the Geriatric Depression Scale (GDS-30). Symptomatic individuals were defined as \u2265 6 on an item of the NMSS; for dementia, a cutoff of \u226418 on the MMSE; for depression, a cutoff of \u226510 on the GDS. Results. All 107 participants exhibited NMS to various degrees and severities; the median NMSS score was 91. Among symptomatic individuals, for depressive symptoms, 37\/63 (59%) were treated with antidepressants; for hallucinations and delusions, 9\/18 (50%) and 5\/13 (38%) were treated with antipsychotics; and for dementia, 9\/27 (33%) were treated with rivastigmine and 1 (4%) was treated with donepezil. For orthostatic hypotension, 11\/19 (58%) with lightheadedness and 7\/8 (88%) with fainting were treated with antihypotensives; for sialorrhea, 2\/42 (5%) were treated with botulinum toxin; and for constipation, 19\/35 (54%) were treated with laxatives. For insomnia, 4\/16 (25%) were treated with hypnotics, and for daytime sleepiness, 1\/29 (3%) was treated with psychostimulants. Conclusions. The present analyses suggest a need for clinicians to further screen for and treat NMS. Optimizing treatment of NMS according to the national and international treatment guidelines may improve symptomatology and enhance quality of life in late-stage PD.<\/jats:p>","DOI":"10.1155\/2023\/6667339","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T22:20:57Z","timestamp":1696976457000},"page":"1-11","source":"Crossref","is-referenced-by-count":3,"title":["Compliance with National and International Guidelines in the Treatment of Nonmotor Symptoms in Late-Stage Parkinson\u2019s Disease"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3861-8012","authenticated-orcid":true,"given":"Kristina","family":"Rosqvist","sequence":"first","affiliation":[{"name":"Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Division of Neurology, Lund, Sweden"},{"name":"Sk\u00e5ne University Hospital, Department of Neurology, Rehabilitation Medicine, Memory and Geriatrics, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0756-7478","authenticated-orcid":true,"given":"Per","family":"Odin","sequence":"additional","affiliation":[{"name":"Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Division of Neurology, Lund, Sweden"},{"name":"Sk\u00e5ne University Hospital, Department of Neurology, Rehabilitation Medicine, Memory and Geriatrics, Lund, Sweden"},{"name":"Department of Neurology, Klinikum Bremen-Nord, Bremen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","article-title":"Nationella riktlinjer f\u00f6r v\u00e5rd vid parkinsons sjukdom","author":"Socialstyrelsen","year":"2016"},{"key":"2","article-title":"Riktlinjer f\u00f6r utredning och behandling av parkinsons sjukdom","author":"Swemodis (Swedish Movement Disorder Society)","year":"2019"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27602"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.17.5.427"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.126"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2020.05.016"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-171181"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-181380"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.13186"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12027"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22643"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23462"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23394"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-015-0281-x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12458"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.62"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22589"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70373-8"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12968"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21596"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-018-1184-3"},{"key":"22","first-page":"152","article-title":"Projection technique for evaluating surgery in Parkinson's disease","volume-title":"Third Symposium on Parkinson's Disease","author":"R. 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