{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T04:49:26Z","timestamp":1763959766428,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"vor","delay-in-days":284,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Asymptomatic esophageal eosinophilia (aEE) is a rare presentation, where patients have increased eosinophils in esophageal mucosa but lack any esophagus\u2010related symptoms. Cases of aEE have only been documented in adults, and little is known about its clinical significance and whether treatment is warranted. We report a case of an 11\u2010year\u2010old patient with uncontrolled severe persistent asthma who underwent flexible bronchoscopy and upper endoscopy as a part of complete aerodigestive evaluation. Elevated intraepithelial eosinophils in the esophageal mucosa were noted, suggesting an aEE\u2010like presentation. This case documents a pediatric patient with aEE and highlights the importance of combined aerodigestive assessment with pulmonology and gastroenterology teams for the evaluation of severe asthma.<\/jats:p>","DOI":"10.1155\/2023\/6678918","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T12:50:06Z","timestamp":1697115006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Asymptomatic Esophageal Eosinophilia in an 11\u2010Year\u2010Old with Severe Persistent Asthma"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2798-1382","authenticated-orcid":false,"given":"Casey E.","family":"Hofstaedter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3152-6446","authenticated-orcid":false,"given":"Runa","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8604-9240","authenticated-orcid":false,"given":"Nidhi","family":"Kotwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,12]]},"reference":[{"key":"e_1_2_5_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(06)69283-0"},{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.03.048"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.12305"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2014.35.3768"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.14920"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doaa105"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.20-49"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14072"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0052-5"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.10.001"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9343(03)00192-x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2022.10.004"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(06)93002-8"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.2165\/00126839-200809020-00006"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/1744666x.2017.1298443"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.14151"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2106567"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.14309\/crj.0000000000000887"}],"container-title":["Case Reports in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2023\/6678918.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripe\/2023\/6678918.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2023\/6678918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:10:09Z","timestamp":1762474209000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2023\/6678918"}},"subtitle":[],"editor":[{"given":"Vjekoslav","family":"Krzelj","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1155\/2023\/6678918"],"URL":"https:\/\/doi.org\/10.1155\/2023\/6678918","archive":["Portico"],"relation":{},"ISSN":["2090-6803","2090-6811"],"issn-type":[{"type":"print","value":"2090-6803"},{"type":"electronic","value":"2090-6811"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"2023-06-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6678918"}}