{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:55:30Z","timestamp":1747191330235,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T00:00:00Z","timestamp":1685145600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Neurological Medicine"],"published-print":{"date-parts":[[2023,5,27]]},"abstract":"<jats:p>The new coronavirus (COVID-19) pandemic has resulted in the unprecedented production of vaccines. In this context, the possible adverse effects remain to be identified and reported. In this article, we report the case of a young female patient who developed anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMG-CoA) immune-mediated necrotizing myositis (IMNM) after receiving the Pfizer-BioNTech (BNT162b2) COVID-19 vaccine. The diagnosis of probable post-vaccination IMNM was made due to the absence of other factors that may have led to the development of autoantibodies (medicines; e.g., statins, drugs) and the temporal relationship between exposure and event. This case report is the first to suggest that a COVID-19 vaccine may trigger anti-HMG-CoA reductase necrotizing myopathy.<\/jats:p>","DOI":"10.1155\/2023\/7061783","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T23:35:06Z","timestamp":1685230506000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Immune-Mediated Necrotizing Myopathy following mRNA SARS-CoV-2 Vaccination"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8616-6735","authenticated-orcid":true,"given":"Marta","family":"Rodrigues de Carvalho","sequence":"first","affiliation":[{"name":"Department of Neurology and Clinical Neurophysiology, Base Hospital of the Federal District, Bras\u00edlia, Distrito Federal, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myrian Mathildes","family":"S\u00e1 de Deus Rocha","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Neurophysiology, Base Hospital of the Federal District, Bras\u00edlia, Distrito Federal, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin\u00edcius","family":"Alves Bezerra","sequence":"additional","affiliation":[{"name":"Department of Radiology, DFSTAR Hospital, Bras\u00edlia, Distrito Federal, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciel Eduardo","family":"de Pontes","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Neurophysiology, Base Hospital of the Federal District, Bras\u00edlia, Distrito Federal, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina","family":"del Negro","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sarah Network of Rehabilitation Hospitals, Bras\u00edlia, Distrito Federal, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio Salgado","family":"Antunes","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sarah Network of Rehabilitation Hospitals, Bras\u00edlia, Distrito Federal, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7819-5563","authenticated-orcid":true,"given":"Vin\u00edcius Viana Abreu","family":"Montanaro","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sarah Network of Rehabilitation Hospitals, Bras\u00edlia, Distrito Federal, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rubens Nelson Morato","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Neurophysiology, Base Hospital of the Federal District, Bras\u00edlia, Distrito Federal, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-020-01401-y"},{"article-title":"Rolling update son coronavirus disease","year":"2020","author":"World Health Organization (Who)","key":"3"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00592-1"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00321-x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30254-0"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3233\/JND-180308"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000832"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3233\/JND-170282"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26729"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-022-00699-2"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05146-w"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000290"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.08.005"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2022.37.e32"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.1007637"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-242095"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27483"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27531"}],"container-title":["Case Reports in Neurological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crinm\/2023\/7061783.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crinm\/2023\/7061783.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crinm\/2023\/7061783.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T23:35:09Z","timestamp":1685230509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crinm\/2023\/7061783\/"}},"subtitle":[],"editor":[{"given":"Massimiliano","family":"Filosto","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,5,27]]},"references-count":20,"alternative-id":["7061783","7061783"],"URL":"https:\/\/doi.org\/10.1155\/2023\/7061783","relation":{},"ISSN":["2090-6676","2090-6668"],"issn-type":[{"type":"electronic","value":"2090-6676"},{"type":"print","value":"2090-6668"}],"subject":[],"published":{"date-parts":[[2023,5,27]]}}}