{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:55:43Z","timestamp":1747191343118,"version":"3.40.5"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:00:00Z","timestamp":1691452800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2023,8,8]]},"abstract":"<jats:p>Leydig cell hyperplasia (LCH) is a rare cause of hyperandrogenism that has been described only in case reports. The cases presented herein contrast the traditional presentation of LCH with an affected asymptomatic individual. The first case involves a 74-year-old woman presenting with symptomatic hyperandrogenism, whose symptoms resolved after bilateral salpingo-oophorectomy (BSO). The second patient presented with postmenopausal bleeding and an abdominal mass. Following total abdominal hysterectomy (TAH) and BSO, pathology showed ovarian LCH with concomitant endometrial cancer. The diagnosis of LCH is complex and requires careful investigation of many differential diagnoses. Incidentally discovered LCH may shed light on evolution and disease progression. Cases of LCH found in the setting of endometrial pathology may have implications on other states of testosterone excess.<\/jats:p>","DOI":"10.1155\/2023\/7178201","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T19:05:06Z","timestamp":1691521506000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["Varying Phenotypes of Leydig Cell Hyperplasia of the Ovary: Two Case Reports"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8824-893X","authenticated-orcid":true,"given":"Margaret","family":"Caulkins","sequence":"first","affiliation":[{"name":"Roswell Park Comprehensive Cancer Institute, Gynecologic Oncology Department, 665 Elm Street, Buffalo, NY 14203, USA"},{"name":"University at Buffalo, The State University of New York, Obstetrics and Gynecology Department, Conventus, 1001 Main Street, Buffalo, NY 14203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Ricciuti","sequence":"additional","affiliation":[{"name":"Roswell Park Comprehensive Cancer Institute, Gynecologic Oncology Department, 665 Elm Street, Buffalo, NY 14203, USA"},{"name":"St. Luke\u2019s Hospital, Gynecologic Oncology Department, 1031 Bellevue Avenue, Suite 400, St. Louis, MO 63117, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Desouki","sequence":"additional","affiliation":[{"name":"Roswell Park Comprehensive Cancer Institute, Pathology Department, 665 Elm Street, Buffalo, NY 14203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine LaVigne","family":"Mager","sequence":"additional","affiliation":[{"name":"Roswell Park Comprehensive Cancer Institute, Gynecologic Oncology Department, 665 Elm Street, Buffalo, NY 14203, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.01.024"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8154513"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.4158\/ep.13.5.472"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.130911"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)65035-0"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9378(97)70580-5"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1990.tb00856.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.18203\/2320-1770.ijrcog20184166"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/762745"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197310)32:4<940::aid-cncr2820320428>3.0.co;2-5"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2013.850661"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.4158\/ep.7.1.40"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2010.21.1.56"},{"key":"14","first-page":"703","article-title":"Hilar-cell tumours of the ovary","volume":"27","author":"D. 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