{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:00:18Z","timestamp":1792569618533,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004001","name":"Guizhou Science and Technology Department","doi-asserted-by":"publisher","award":["LC[2022]022"],"award-info":[{"award-number":["LC[2022]022"]}],"id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2023,3,7]]},"abstract":"<jats:p>Objective. To evaluate the analgesic efficacy and safety of different does of intravenous ibuprofen (IVIB) in the treatment of postoperative acute pain. Methods. Patients with an intravenous (IV) patient-controlled analgesia device after abdominal or orthopedic surgery were randomly divided into placebo, IVIB 400\u2009mg, and IVIB 800\u2009mg groups. The first dosage of study medicines was given intravenously 30\u2009minutes (min) before surgery ended, followed by six hours (h) intervals for a total of eight doses following surgery. The demographic characteristics and procedure data, cumulative morphine consumption, the visual analog scale (VAS), the area under the curve (AUC) of VAS, patient satisfaction score (PSS), the rates of treatment failure (RTF), and adverse events (AEs) and serious adverse event (SAEs) were recorded during the period of trial. Result. A total of 345 patients were enrolled in the full analysis set (FAS), and of 326 participants were valid data set (VDS). Demographic characteristics, disease features, and medical history of patients were not significantly different between groups. Total morphine consumption of the IVIB 400\u2009mg group (11.14\u2009\u00b1\u20097.14\u2009mg; <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula>\u2009=\u20090.0011) and the IVIB 800\u2009mg group (11.29\u2009\u00b1\u20096.45\u2009mg; <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                     <\/c:math>\n                  <\/jats:inline-formula>\u2009=\u20090.0014) was significantly reduced compared with the placebo group (14.51\u2009\u00b1\u20099.19\u2009mg) for 24\u2009h postoperatively, there was no significant difference between the IVIB 400\u2009mg and IVIB 800\u2009mg groups (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                     <\/e:math>\n                  <\/jats:inline-formula>\u2009=\u20090.9997). The placebo group had significantly higher VAS and the AUCs of VAS than those in the IVIB 400\u2009mg and the IVIB 800\u2009mg groups at rest and movement for 24\u2009h postoperatively (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                     <\/g:math>\n                  <\/jats:inline-formula>\u2009&lt;\u20090.05), and there was no significant difference between the IVIB 400\u2009mg and IVIB 800\u2009mg groups (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                     <\/i:math>\n                  <\/jats:inline-formula>\u2009&gt;\u20090.05). RTF was slightly higher in the placebo group than IVIB 400\u2009mg group and 800\u2009mg group, and no statistical significance (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                     <\/k:math>\n                  <\/jats:inline-formula>\u2009&lt;\u20090.690). PSS in the IVIB 400\u2009mg (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>P<\/m:mi>\n                     <\/m:math>\n                  <\/jats:inline-formula>\u2009=\u20090.0092) and the IVIB 800\u2009mg groups (<jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>P<\/o:mi>\n                     <\/o:math>\n                  <\/jats:inline-formula>\u2009=\u20090.0011) was higher than the placebo group for pain management, there was also no significant difference between the IVIB 400\u2009mg and IVIB 800\u2009mg groups (<jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mi>P<\/q:mi>\n                     <\/q:math>\n                  <\/jats:inline-formula>\u2009=\u20090.456). The incidence of RTF (<jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mi>P<\/s:mi>\n                     <\/s:math>\n                  <\/jats:inline-formula>\u2009=\u20090.690) and AEs (<jats:inline-formula>\n                     <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <u:mi>P<\/u:mi>\n                     <\/u:math>\n                  <\/jats:inline-formula>\u2009&gt;\u20090.05) were not different among the three groups. Conclusion. Intermittent IV administration of ibuprofen 400\u2009mg or 800\u2009mg within 24\u2009h after surgery in patients undergoing abdominal and orthopedic surgery significantly decreased morphine consumption and relieved pain, without increasing the incidence of AEs.<\/jats:p>","DOI":"10.1155\/2023\/7768704","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T08:44:45Z","timestamp":1678351485000},"page":"1-12","source":"Crossref","is-referenced-by-count":9,"title":["Analgesic Efficacy of Intravenous Ibuprofen in the Treatment of Postoperative Acute Pain: A Phase III Multicenter Randomized Placebo-ControlledDouble-Blind Clinical Trial"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3337-8168","authenticated-orcid":true,"given":"Hong-Su","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6041-6719","authenticated-orcid":true,"given":"Ting-Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2499-7605","authenticated-orcid":true,"given":"Yu","family":"Pi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, South West Medical University, Luzhou 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2012-8936","authenticated-orcid":true,"given":"Ting-Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, China"},{"name":"Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9970-1338","authenticated-orcid":true,"given":"Fei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610044, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1623-5969","authenticated-orcid":true,"given":"Liu-Lin","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnz149"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12751"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0b013e31828866b3"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/935194"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000074660.05733.10"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.143.10.990"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.06.035"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1177\/204946371100500306"},{"key":"9","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1097\/00000542-199504000-00032","article-title":"Practice guidelines for acute pain management in the perioperative setting. 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