{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:44:15Z","timestamp":1764175455055,"version":"3.37.3"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","award":["LGKCYLWS2018000195"],"award-info":[{"award-number":["LGKCYLWS2018000195"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004702","name":"Baxter","doi-asserted-by":"crossref","award":["LGKCYLWS2018000195"],"award-info":[{"award-number":["LGKCYLWS2018000195"]}],"id":[{"id":"10.13039\/100004702","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shenzhen Medical Science and Technology Program","award":["LGKCYLWS2018000195"],"award-info":[{"award-number":["LGKCYLWS2018000195"]}]},{"name":"Project DEAL","award":["LGKCYLWS2018000195"],"award-info":[{"award-number":["LGKCYLWS2018000195"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Nephrology"],"published-print":{"date-parts":[[2023,9,27]]},"abstract":"<jats:p>Introduction. Due to chronic inflammation, maintenance hemodialysis (MHD) patients continue to show excess mortality. Acetate-free citrate-buffered A concentrates could be a way to improve the biocompatibility of the procedure, reduce chronic inflammation, and thus in the long term improve the prognosis of patients. Methods. Using a pre-post design (3\u2009months of acetate followed by 3\u2009months of citrate-acidified A concentrates in standard bicarbonate-based dialysate hemodialysis, CiaHD) and linear mixed model analysis in 61 stable HD patients, we assessed the impact of CiaHD on counts and phenotypes of peripheral T cells and monocytes by flow cytometry. Results. Switching to CiaHD left C-reactive protein (CRP) levels and leucocyte counts unaffected. However, CiaHD increased lymphocyte counts ex vivo. Furthermore, we found a decrease in total CD3+CD4+CD69+ ((109\/L), mean\u2009\u00b1\u2009SD: acetate, 0.04\u2009\u00b1\u20091.0 versus citrate, 0.02\u2009\u00b1\u20090.01; <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula>\u2009=\u20090.02) activated cells, while the number of CD28+ T cells remained stable. No differences were noted regarding T-cell exhaustion marker expression, CD14+CD16+ monocyte counts, and PMN-MDSCs. Conclusion. Compared with acetate, CiaHD has a minor impact on lymphocyte counts and CD4+T-cell activation, which was independent of systemic CRP and ionized magnesium, calcium levels, and other dialysis prescription modalities.<\/jats:p>","DOI":"10.1155\/2023\/7772677","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T20:20:08Z","timestamp":1695846008000},"page":"1-10","source":"Crossref","is-referenced-by-count":2,"title":["Immunophenotypic Characterization of Citrate-Containing A Concentrates in Maintenance Hemodialysis: A Pre-Post Study"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4895-7066","authenticated-orcid":true,"given":"Yuli","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Nephrology, School of Medicine, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany"},{"name":"Nephrology and Rheumatology Department of the Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People\u2019s Hospital of Shenzhen, Shenzhen 518172, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5803-2190","authenticated-orcid":true,"given":"Christoph","family":"Schmaderer","sequence":"additional","affiliation":[{"name":"Department of Nephrology, School of Medicine, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany"},{"name":"German Centre for Infection Research (DZIF), Partner Site Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5546-5524","authenticated-orcid":true,"given":"Andreas","family":"Ossadnik","sequence":"additional","affiliation":[{"name":"Department of Nephrology, School of Medicine, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2658-4764","authenticated-orcid":true,"given":"Arianne","family":"Hammitzsch","sequence":"additional","affiliation":[{"name":"Department of Nephrology, School of Medicine, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5017-6202","authenticated-orcid":true,"given":"Javier","family":"Carbajo-Lozoya","sequence":"additional","affiliation":[{"name":"Department of Nephrology, School of Medicine, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quirin","family":"Bachmann","sequence":"additional","affiliation":[{"name":"Department of Nephrology, School of Medicine, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Bonell","sequence":"additional","affiliation":[{"name":"Department of Nephrology, School of Medicine, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias Christoph","family":"Braunisch","sequence":"additional","affiliation":[{"name":"Department of Nephrology, School of Medicine, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3886-2517","authenticated-orcid":true,"given":"Uwe","family":"Heemann","sequence":"additional","affiliation":[{"name":"Department of Nephrology, School of Medicine, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dang","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Nephrology, School of Medicine, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1242-4914","authenticated-orcid":true,"given":"Stephan","family":"Kemmner","sequence":"additional","affiliation":[{"name":"Department of Nephrology, School of Medicine, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4914-8773","authenticated-orcid":true,"given":"Georg","family":"Lorenz","sequence":"additional","affiliation":[{"name":"Department of Nephrology, School of Medicine, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.09.003"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139x.2010.00784.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00637.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3390\/toxins12070439"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.0550031081.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3390\/toxins13010070"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1681\/asn.v131204"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2016010053"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12309"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1080\/0886022x.2017.1349672"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2019.03.008"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009731107"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.583702"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.7.1027"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.0590041382.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.2215\/cjn.03260509"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1070959"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12084"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2016.0125"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.12.015"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2011.00976.x"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1159\/000346293"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2018.09.010"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy134"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw461"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1038\/475462a"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1038\/nature10246"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12859-6"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.413"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1056\/nejm197704072961401"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1097\/01.asn.0000143744.72664.66"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1159\/000096471"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47040-8"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1007\/s13730-020-00466-w"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-14-216"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1159\/000513419"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.04.022"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-015-0225-y"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001550"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-020-01920-8"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.644627"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12150"}],"container-title":["International Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijn\/2023\/7772677.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijn\/2023\/7772677.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijn\/2023\/7772677.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T20:20:16Z","timestamp":1695846016000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ijn\/2023\/7772677\/"}},"subtitle":[],"editor":[{"given":"Martin","family":"Sedlacek","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,9,27]]},"references-count":42,"alternative-id":["7772677","7772677"],"URL":"https:\/\/doi.org\/10.1155\/2023\/7772677","relation":{},"ISSN":["2090-2158","2090-214X"],"issn-type":[{"type":"electronic","value":"2090-2158"},{"type":"print","value":"2090-214X"}],"subject":[],"published":{"date-parts":[[2023,9,27]]}}}