{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T21:49:36Z","timestamp":1782337776828,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnolo\u0161kog Razvoja","doi-asserted-by":"publisher","award":["451-03-68"],"award-info":[{"award-number":["451-03-68"]}],"id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2023,4,24]]},"abstract":"<jats:p>Objective. The aim of the present study was to compare periodontal status and antioxidant profile in unstimulated saliva of systemic sclerosis (SSc) patients with periodontitis and systemically healthy periodontitis patients. Design. Twenty patients with established diagnoses of systemic sclerosis and periodontitis (SSc group) and 20 systemically healthy individuals with periodontitis (P group) were enrolled in the study. Clinical periodontal parameters (clinical attachment level (CAL), gingival recession (GR), periodontal probing depth (PPD), and gingival index (GI)) and concentration of uric acid (UA), superoxide dismutase (SOD), and glutathione peroxidase (GPX) in unstimulated saliva samples were assessed. Results. There were significantly higher mean values of CAL (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mn>4.8<\/a:mn>\n                        <a:mo>\u00b1<\/a:mo>\n                        <a:mn>0.21<\/a:mn>\n                        <a:mtext>\u2009<\/a:mtext>\n                        <a:mtext>mm<\/a:mtext>\n                     <\/a:math>\n                  <\/jats:inline-formula> versus <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mn>3.18<\/c:mn>\n                        <c:mo>\u00b1<\/c:mo>\n                        <c:mn>0.17<\/c:mn>\n                        <c:mtext>\u2009<\/c:mtext>\n                        <c:mtext>mm<\/c:mtext>\n                     <\/c:math>\n                  <\/jats:inline-formula>; <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>\u2264<\/e:mo>\n                        <e:mn>0.001<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>) and GR (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mn>1.66<\/g:mn>\n                        <g:mo>\u00b1<\/g:mo>\n                        <g:mn>0.90<\/g:mn>\n                        <g:mtext>\u2009<\/g:mtext>\n                        <g:mtext>mm<\/g:mtext>\n                     <\/g:math>\n                  <\/jats:inline-formula> versus <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mn>0.46<\/i:mn>\n                        <i:mo>\u00b1<\/i:mo>\n                        <i:mn>0.54<\/i:mn>\n                        <i:mtext>\u2009<\/i:mtext>\n                        <i:mtext>mm<\/i:mtext>\n                     <\/i:math>\n                  <\/jats:inline-formula>; <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>p<\/k:mi>\n                        <k:mo>\u2264<\/k:mo>\n                        <k:mn>0.001<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>) in the SSc group when compared to the P group. Significantly higher level of GPX (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>p<\/m:mi>\n                        <m:mo>\u2264<\/m:mo>\n                        <m:mn>0.001<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>) and SOD (<jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>p<\/o:mi>\n                        <o:mo>\u2264<\/o:mo>\n                        <o:mn>0.001<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>) in unstimulated saliva was detected in the SSc group in comparison with the P group. The specific activity of UA did not significantly differ between the two groups (<jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mi>p<\/q:mi>\n                        <q:mo>=<\/q:mo>\n                        <q:mn>0.083<\/q:mn>\n                     <\/q:math>\n                  <\/jats:inline-formula>). Conclusion. The results may indicate higher periodontal destruction and antioxidant perturbations in unstimulated saliva of SSc patients with periodontitis compared to systemically healthy periodontitis patients.<\/jats:p>","DOI":"10.1155\/2023\/7886272","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T18:05:08Z","timestamp":1682359508000},"page":"1-8","source":"Crossref","is-referenced-by-count":6,"title":["Salivary Antioxidant Profile in Patients with Systemic Sclerosis and Periodontitis"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9874-1699","authenticated-orcid":true,"given":"Stefan I.","family":"Sredojevic","sequence":"first","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine, University of Belgrade, Dr Subotica 4, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2366-9244","authenticated-orcid":true,"given":"Slavica Pavlov","family":"Dolijanovic","sequence":"additional","affiliation":[{"name":"Institute of Rheumatology, School of Medicine, University of Belgrade, Resavska 69, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6085-5236","authenticated-orcid":true,"given":"Ivan","family":"Dozic","sequence":"additional","affiliation":[{"name":"General and Oral Biochemistry, School of Dental Medicine, University of Belgrade, Dr Subotica 4, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5397-9361","authenticated-orcid":true,"given":"Jovana Kuzmanovic","family":"Pficer","sequence":"additional","affiliation":[{"name":"Biomedical Statistics and Informatics, School of Dental Medicine, University of Belgrade, Dr Subotica 4, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0390-8789","authenticated-orcid":true,"given":"Zoran","family":"Aleksic","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine, University of Belgrade, Dr Subotica 4, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8418-2395","authenticated-orcid":true,"given":"Natasa S.","family":"Nikolic-Jakoba","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine, University of Belgrade, Dr Subotica 4, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.062901"},{"issue":"2","key":"2","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis","volume":"15","author":"E. 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