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Many mechanisms are involved in causing hypertension, i.e., via calcium channels, alpha and beta receptors, and the renin-angiotensin system (RAS). RAS has an important role in blood pressure control and is also involved in the metabolism of glucose, homeostasis, and balance of electrolytes in the body. The components of RAS that are involved in the regulation of blood pressure are angiotensinogen, Ang I (angiotensin I), Ang II (angiotensin II), ACE (angiotensin-converting enzyme), and ACE 2 (angiotensin-converting enzyme 2). These components provide for relevant therapeutic targets for the treatment of hypertension, and various drugs are commercially available that target individual components of RAS. Angiotensin receptor blockers (ARBs) and ACE inhibitors are the most popular among these drugs. ACE is chosen in this review as it makes an important target for blood pressure control because it converts Ang I into Ang II and also acts on the vasodilator, bradykinin, to degrade it into inactive peptides. This review highlights various aspects of blood pressure regulation in the body with a focus on ACE, drugs targeting the components involved in regulation, their associated side effects, and a need to shift to alternative therapy for putative hypertension treatment in the form of bioactive peptides from food.<\/jats:p>","DOI":"10.1155\/2023\/7890188","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T18:21:11Z","timestamp":1687371671000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":127,"title":["Angiotensin-Converting Enzyme and Hypertension: A Systemic Analysis of Various ACE Inhibitors, Their Side Effects, and Bioactive Peptides as a Putative Therapy for Hypertension"],"prefix":"10.1177","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9366-3502","authenticated-orcid":false,"given":"Hafiz","family":"Ahmad","sequence":"first","affiliation":[{"name":"RAK College of Medical SciencesRAK Medical & Health Sciences UniversityRas al KhaimahUAE"},{"name":"Microbiology and Molecular Division-RAK HospitalRas al KhaimahUAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9878-6878","authenticated-orcid":false,"given":"Huma","family":"Khan","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology and Applied SciencesShoolini University of Biotechnology and Management SciencesSolanIndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6721-0630","authenticated-orcid":false,"given":"Shabirul","family":"Haque","sequence":"additional","affiliation":[{"name":"The Feinstein Institute of Medical ResearchNorthwell HealthManhassetNYUSA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1877-9994","authenticated-orcid":false,"given":"Shameem","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of OrthopedicsLady Hardinge Medical CollegeNew DelhiIndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4029-5232","authenticated-orcid":false,"given":"Namita","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology and Applied SciencesShoolini University of Biotechnology and Management SciencesSolanIndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2570-8219","authenticated-orcid":false,"given":"Azhar","family":"Khan","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology and Applied SciencesShoolini University of Biotechnology and Management SciencesSolanIndia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"bibr1-2023_7890188","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000076"},{"key":"bibr2-2023_7890188","doi-asserted-by":"publisher","DOI":"10.23856\/2515"},{"key":"bibr3-2023_7890188","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-014-0306-5"},{"key":"bibr4-2023_7890188","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(02)00164-2"},{"key":"bibr5-2023_7890188","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2009.00179.x"},{"key":"bibr6-2023_7890188","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3281fc975a"},{"key":"bibr7-2023_7890188","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12237"},{"key":"bibr8-2023_7890188","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4098"},{"key":"bibr9-2023_7890188","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-010-0099-1"},{"key":"bibr10-2023_7890188","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.328.7440.634"},{"issue":"4","key":"bibr11-2023_7890188","first-page":"358","volume":"19","author":"Baradaran A.","year":"2014","journal-title":"Journal of Research in Medical Sciences"},{"key":"bibr12-2023_7890188","first-page":"I4","volume":"77","author":"Dzau V. 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