{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:12:53Z","timestamp":1790280773104,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p><jats:italic>Objective.<\/jats:italic> We conducted this meta\u2010analysis to provide better evidence of the efficacy of manual therapy (MT) on adolescent idiopathic scoliosis (AIS). <jats:italic>Methods.<\/jats:italic> All RCTs of MT for the management of patients with AIS were included in the present study. The treatment difference between the experimental and control group was mainly MT. The outcomes consisted of the total effective rate, the Cobb angle, and Scoliosis Research Society\u201022 (SRS\u201022) questionnaire score. Electronic database searches were conducted from database inception to July 2022, including the Cochrane Library, PubMed, Web of Science, Embase, Wanfang Data, CNKI, and VIP. The pooled data were analyzed using RevMan 5.4 software. <jats:italic>Results.<\/jats:italic> Four RCTs with 213 patients in the experimental group were finally included. There are 2 studies of standalone MT in the experimental group and 3 studies of MT with identical conservative treatments in the control group. Three trials reported total effective rate, and a statistically significant difference was found (<jats:italic>P<\/jats:italic> = 0.004). Three trials reported Cobb angle, and a statistical difference was found (<jats:italic>P<\/jats:italic> = 0.01). Then, sensitivity analysis showed that there was a significant difference in the additional MT subgroup (<jats:italic>P<\/jats:italic> &lt; 0.00001) while not in the standalone MT subgroup (<jats:italic>P<\/jats:italic> = 0.41). Three trials reported SRS\u201022 scores (<jats:italic>P<\/jats:italic> = 0.55) without significant differences. <jats:italic>Conclusion.<\/jats:italic> There is insufficient data to determine the effectiveness of spinal manipulation limited by the very low quality of included studies. High\u2010quality studies with appropriate design and follow\u2010up periods are warranted to determine if MT may be beneficial as an adjunct therapy for AIS. Currently, there is no evidence to support spinal manipulation.<\/jats:p>","DOI":"10.1155\/2023\/7928429","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T19:05:05Z","timestamp":1672859105000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Spinal Manual Therapy for Adolescent Idiopathic Scoliosis: A Systematic Review and Meta\u2010Analysis of Randomized Controlled 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