{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:08:27Z","timestamp":1771466907556,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. The aim of this study is to evaluate the clinical efficacy of Tongxinluo capsules in preventing coronary restenosis based on meta\u2010analysis and network pharmacology research methods and to preliminarily explore its intervention mechanism. <jats:italic>Methods<\/jats:italic>. First, through meta\u2010analysis, we comprehensively searched databases such as CNKI, Wanfang, PubMed, the Cochrane Library, and Web of Science to find out the randomized controlled trials of Tongxinluo capsules in the treatment of coronary restenosis until February, 2022. According to the Cochrane Library, risk bias assessment tools were used to evaluate the included literature and Review Manager 5.2 software was used to conduct statistical analysis of the included studies. Then, based on network pharmacology, through TCMSP database and BATMAN\u2010TCM database screening, the chemical components of Tongxinluo capsules and their related effects, symptom, and common targets were analyzed. String net was used to construct protein\u2010protein interaction (PPI) network, and R3.6.1 software was used to carry out GO biological process enrichment analysis and KEGG signaling pathway enrichment analysis to clarify key pathways. <jats:italic>Results<\/jats:italic>. The meta\u2010analysis finally included 10 RCTs with a total of 1318 subjects. Meta\u2010analysis results showed that Tongxinluo capsules combined with conventional cardiovascular drugs could significantly improve the clinical efficacy of preventing in\u2010stent restenosis and the clinical efficacy of preventing angina pectoris. There was no significant difference in the clinical efficacy of preventing myocardial infarction. Network pharmacology obtained a total of 101 chemical components and 149 targets through the online database. The results of network analysis showed that the targets were mainly involved in receptor ligand activity, carboxylic acid binding, steroid hormone receptor activity, and other related action pathways and were also involved in AGE\u2010RAGE signaling pathway, cell senescence signaling pathway, and other related pathways. <jats:italic>Conclusion<\/jats:italic>. Tongxinluo capsules combined with conventional cardiovascular drugs can improve the clinical efficacy of preventing in\u2010stent restenosis and angina pectoris and have a significant effect on reducing inflammatory factors. The comprehensive result of the effect is mainly through the participation of receptor ligand activity, carboxylic acid binding, steroid hormone receptor activity, and other ways to achieve the purpose of treating coronary restenosis.<\/jats:p>","DOI":"10.1155\/2023\/7985459","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T18:52:02Z","timestamp":1674845522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["To Investigate the Clinical Efficacy and Potential Mechanism of Tongxinluo Capsules in Preventing Coronary Restenosis Based on Meta\u2010Analysis and Network Pharmacology Analysis"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1809-1460","authenticated-orcid":false,"given":"Wen-Xin","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3294-2110","authenticated-orcid":false,"given":"Yi-Hao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"e_1_2_7_1_2","first-page":"26","article-title":"China cardiovascular health and disease report 2021 summary","volume":"22","author":"Chinese Cardiovascular Health and Disease Report Compilation Group","year":"2022","journal-title":"Cardio-Cerebrovasc Disease Prevention Treat"},{"key":"e_1_2_7_2_2","first-page":"19","article-title":"Chinese Pharmacists Association. Guidelines for rational drug use in coronary heart disease","volume":"8","author":"Expert Committee on Rational Drug Use of National Health and Family Planning Commission","year":"2016","journal-title":"Chinese journal of medical frontiers (electronic edition)"},{"key":"e_1_2_7_3_2","first-page":"948","article-title":"Clinico pathological characteristics of coronary heart disease in elderly patients aged 80 years and older","volume":"43","author":"Wang H.","year":"2015","journal-title":"Chinese Journal of Cardiovascular Disease"},{"key":"e_1_2_7_4_2","first-page":"378","article-title":"CT imaging with different iodine concentration for evaluation of coronary artery stents","volume":"35","author":"Chunrong Z.","year":"2016","journal-title":"Journal of Cardiopulmonary Vascular Disease"},{"key":"e_1_2_7_5_2","first-page":"309","article-title":"Coronary artery stenting: a review","volume":"35","author":"Chunrong Z.","year":"2016","journal-title":"Coronary Artery Stenting"},{"key":"e_1_2_7_6_2","first-page":"1275","article-title":"Effect of Guanxin Shutong capsule on critical coronary artery disease and its influence on quality of life","volume":"14","author":"Yang C.","year":"2016","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine Cardio-Cerebrovascular Diseases"},{"key":"e_1_2_7_7_2","first-page":"224","article-title":"Clinical Study of Tongxinluo Capsule and Wanshuang Li on Restenosis after PCI","author":"Feng Q.","year":"2012","journal-title":"Basic and Clinical Research of Collateral Diseases"},{"key":"e_1_2_7_8_2","first-page":"2117","article-title":"Clinical observation of Tongxinluo Capsule combined with Western medicine in prevention of coronary artery restenosis after percutaneous coronary intervention: a report of 90 cases","volume":"55","author":"Hongwei L.","year":"2014","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"e_1_2_7_9_2","first-page":"54","article-title":"Effect of prostaglandin E1 injection combined with Tongxinluo Capsule on inflammatory factors and restenosis after PCI","volume":"35","author":"Mingxiang T.","year":"2015","journal-title":"Journal of Human University of Traditional Chinese Medicine"},{"key":"e_1_2_7_10_2","first-page":"464","article-title":"Effect of Tongxinluo capsule on restenosis after stenting of coronary artery long vessel lesions in type 2 diabetes mellitus","volume":"26","author":"Xindong W.","year":"2010","journal-title":"Journal of Nanjing University of Traditional Chinese Medicine"},{"key":"e_1_2_7_11_2","first-page":"175","article-title":"Effect of Tongxinluo capsule on restenosis in patients with coronary artery interventional therapy after myocardial infarction","volume":"17","author":"Yanmin L.","year":"2010","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine Emergency Treatment"},{"key":"e_1_2_7_12_2","first-page":"67","article-title":"Clinical observation of Tongxinluo capsule in the intervention of restenosis of coronary heart disease after PCI","volume":"3","author":"Xianda D.","year":"2013","journal-title":"Drug & Clinical"},{"key":"e_1_2_7_13_2","first-page":"191","article-title":"Clinical study of tongxinluo capsule on restenosis after PCI in patients with coronary heart disease","volume":"5","author":"Fu-mei Y.","year":"2006","journal-title":"Intractable Diseases"},{"key":"e_1_2_7_14_2","first-page":"644","article-title":"Effect of Tongxinluo capsule combined with atorvastatin on restenosis and inflammatory factors in stent after PCI","volume":"35","author":"Tian F.","year":"2017","journal-title":"Huaihai Pharmaceutical"},{"key":"e_1_2_7_15_2","first-page":"490","article-title":"Effect of Tongxinluo capsule combined with atorvastatin on stent restenosis after percutaneous coronary intervention and its inflammatory factors","volume":"21","author":"Yang Z.","year":"2018","journal-title":"Chinese Journal of Clinical Hepatology"},{"key":"e_1_2_7_16_2","first-page":"341","article-title":"Effect of Tongxinluo capsule combined with pioglitazone on in-stent restenosis in patients with type 2 diabetes mellitus and coronary artery disease: a prospective, randomized, parallel placebo-controlled study","volume":"24","author":"Tieli Y.","year":"2016","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine First Aid"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2023\/7985459.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2023\/7985459.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2023\/7985459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T15:55:32Z","timestamp":1722959732000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2023\/7985459"}},"subtitle":[],"editor":[{"given":"Jorddy Neves","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1155\/2023\/7985459"],"URL":"https:\/\/doi.org\/10.1155\/2023\/7985459","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"2022-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7985459"}}