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The clinical management of nonacid gastroesophageal reflux-induced chronic cough (GERC) is challenging, and patient response to standard antireflux therapy (omeprazole 20\u2009mg twice daily plus mosapride 10\u2009mg thrice daily) is suboptimal. This study aimed to identify predictors of standard antireflux therapy efficacy and provide evidence for standardized management algorithms of nonacid GERC. Methods. A total of 115 nonacid GERC patients who underwent multichannel intraluminal impedance-pH monitoring (MII-pH) were enrolled between March 2017 and March 2021. Retrospective analysis of general information and MII-pH indications were used to establish a regression analysis model for multiple factors affecting standard antireflux therapy efficacy. Results. 90 patients met the inclusion criteria, and the overall response rate to standard antireflux therapy was 55.5% (50\/90). The mean nocturnal baseline impedance (MNBI) (1817.75\u2009\u00b1\u2009259.26 vs. 2369.93\u2009\u00b1\u2009326.35, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.030<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) and proximal MNBI (1833.39\u2009\u00b1\u200992.16 vs. 2742.57\u2009\u00b1\u2009204.64, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>\u2264<\/c:mo>\n                        <c:mn>0.001<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>) of responders were lower than those of nonresponders. Weakly acid reflux (56.00 (31.70, 86.00) vs. 14.00 (14.00, 44.20), <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.022<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>), nonacid reflux (61.35 (15.90.86.50) vs. 21.60 (0.00, 52.50), <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.008<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>), and proximal extent (19.00 (5.04, 24.00) vs. 5.50 (2.56, 11.13), <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>0.011<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>) were markedly higher in responders than nonresponders. Proximal MNBI (OR\u2009=\u20090.997, <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>0.042<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>, and optimal cutoff\u2009=\u20092140\u2009\u03a9) and weakly acid reflux (OR\u2009=\u20091.051, <jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>P<\/m:mi>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>0.029<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>, and optimal cutoff\u2009=\u200945) were independent predictors of standard antireflux therapy efficacy. The combination predictive value did not show better results than either individual predictor. Conclusions. Proximal MNBI\u2009&lt;\u20092140\u2009\u03a9 may be used to screen patients with nonacid GERC suitable for standard antireflux therapy and in standardized management algorithms for nonacid GERC. In the absence of MNBI, weakly acid reflux\u2009&gt;\u200945 can be used as an auxiliary indicator.<\/jats:p>","DOI":"10.1155\/2023\/7992062","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T17:02:18Z","timestamp":1678554138000},"page":"1-9","source":"Crossref","is-referenced-by-count":6,"title":["Mean Nocturnal Baseline Impedance (MNBI) Provides Evidence for Standardized Management Algorithms of Nonacid Gastroesophageal Reflux-Induced Chronic Cough"],"prefix":"10.1155","volume":"2023","author":[{"given":"Yiqing","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongyangzi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, 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