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Numerous research studies have shown the possibility of treating abnormal semen samples with some drugs before artificial insemination, yet evidence of the drug\u2019s effectiveness remains minimal. In our previous work, we tested the effectiveness of some essential oils, such as eucalyptus (Eucalyptus globulus Labill.), oregano (Origanum vulgare L.), and sage (Salvia officinalis L.) on sperm parameters. The essential oil of oregano showed the best ameliorative effect. In present, we examined the effect of the essential oil of O. vulgare on the physiological parameters and the specific activity of certain antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), lipid peroxidation rate (MDA), and GAPDH and antioxidant and metabolic biomarkers, characterizing the quality of human sperm. The results showed that in vitro supplementation of oregano significantly improves the mobility and antioxidant activities, without harmful effects on the integrity of the sperm\u2019s DNA, and that the selected concentration of oregano EO is nontoxic and may be considered a therapeutic alternative to heal sperm motility problems in asthenozoospermic patients.<\/jats:p>","DOI":"10.1155\/2023\/8093795","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T22:35:05Z","timestamp":1687818905000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["The Impact of Origanum vulgare Supplementation on Human Asthenozoospermic Sperm Parameter Quality"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7027-5013","authenticated-orcid":true,"given":"Ahlam","family":"Zarhouti","sequence":"first","affiliation":[{"name":"Laboratory of Physiopathology, Molecular Genetics & Biotechnology, Faculty of Sciences Ain Chock, Health and Biotechnology Research Centre, Hassan II University of Casablanca, Maarif B.P 5366, Casablanca, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0742-8080","authenticated-orcid":true,"given":"Moudou M.","family":"Mbaye","sequence":"additional","affiliation":[{"name":"Laboratory of Physiopathology, Molecular Genetics & Biotechnology, Faculty of Sciences Ain Chock, Health and Biotechnology Research Centre, Hassan II University of Casablanca, Maarif B.P 5366, Casablanca, Morocco"},{"name":"Laboratory of Medical Analysis, Andrology, LABOMAC, Casablanca, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4190-8878","authenticated-orcid":true,"given":"Boutaina","family":"Addoum","sequence":"additional","affiliation":[{"name":"Laboratory of Physiopathology, Molecular Genetics & Biotechnology, Faculty of Sciences Ain Chock, Health and Biotechnology Research Centre, Hassan II University of Casablanca, Maarif B.P 5366, Casablanca, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6897-8767","authenticated-orcid":true,"given":"Noureddine","family":"Louanjli","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Analysis, Andrology, LABOMAC, Casablanca, Morocco"},{"name":"IRIFIV In Vitro Fertilization Centre, IRIS Clinic, Casablanca, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1318-6233","authenticated-orcid":true,"given":"Bouchra","family":"El Khalfi","sequence":"additional","affiliation":[{"name":"Laboratory of Physiopathology, Molecular Genetics & Biotechnology, Faculty of Sciences Ain Chock, Health and Biotechnology Research Centre, Hassan II University of Casablanca, Maarif B.P 5366, Casablanca, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3288-2901","authenticated-orcid":true,"given":"Abdelaziz","family":"Soukri","sequence":"additional","affiliation":[{"name":"Laboratory of Physiopathology, Molecular Genetics & Biotechnology, Faculty of Sciences Ain Chock, Health and Biotechnology Research Centre, Hassan II University of Casablanca, Maarif B.P 5366, Casablanca, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.4788"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32667-2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S241099"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.10.021"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163524"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-018-1363-6"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10071025"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.aju.2017.11.001"},{"key":"9","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-030-32300-4","volume-title":"Male Infertility","author":"S. 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