{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:34:10Z","timestamp":1789176850179,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007865","name":"Stichting Rotterdams Kinderrevalidatie Fonds Adriaanstichting","doi-asserted-by":"publisher","award":["2014\/0117-110"],"award-info":[{"award-number":["2014\/0117-110"]}],"id":[{"id":"10.13039\/501100007865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007865","name":"Stichting Rotterdams Kinderrevalidatie Fonds Adriaanstichting","doi-asserted-by":"publisher","award":["2014037"],"award-info":[{"award-number":["2014037"]}],"id":[{"id":"10.13039\/501100007865","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Phelps Stichting","award":["2014\/0117-110"],"award-info":[{"award-number":["2014\/0117-110"]}]},{"name":"Phelps Stichting","award":["2014037"],"award-info":[{"award-number":["2014037"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Occupational Therapy International"],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:p>Aim. To explore the effect of an Early Intensive-Upper Limb intervention (EI-UL) compared to EI-UL with integrated Multisensory Stimulation And Priming (MuSSAP) training on improving manual ability in infants with a unilateral brain lesion. Method. A pilot randomised clinical trial with pre- and postintervention and follow-up measurements (T0, T1, and T2) was conducted. Sixteen infants with a unilateral brain lesion (corrected age is 4-10 months) received home-based intervention with video coaching. Eight infants received EI-UL and eight infants received EI-UL with integrated MuSSAP training. Primary outcome was the Hand Assessment for Infants (HAI) score. Additionally, effects were explored on initiation of goal-directed movements in both groups and on attention in the EI-UL with integrated MuSSAP training group. Results. No significant group differences in HAI scores were found. Overall, HAI \u2018Affected hand score\u2019 increased between T0 and T1 (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mtext>Cohen<\/c:mtext>\n                        <c:mtext>\u2019<\/c:mtext>\n                        <c:mtext>s<\/c:mtext>\n                        <c:mtext>\u2009<\/c:mtext>\n                        <c:mtext>d<\/c:mtext>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>1.04<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>) and between T0 and T2 (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.001<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mtext>Cohen<\/g:mtext>\n                        <g:mtext>\u2019<\/g:mtext>\n                        <g:mtext>s<\/g:mtext>\n                        <g:mtext>\u2009<\/g:mtext>\n                        <g:mtext>d<\/g:mtext>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>1.28<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>); and the HAI \u2018Both Hands Measure\u2019 increased between T0 and T1 (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.001<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mtext>Cohen<\/k:mtext>\n                        <k:mtext>\u2019<\/k:mtext>\n                        <k:mtext>s<\/k:mtext>\n                        <k:mtext>\u2009<\/k:mtext>\n                        <k:mtext>d<\/k:mtext>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>1.72<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>) and between T0 and T2 (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>p<\/m:mi>\n                        <m:mo>&lt;<\/m:mo>\n                        <m:mn>0.001<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mtext>Cohen<\/o:mtext>\n                        <o:mtext>\u2019<\/o:mtext>\n                        <o:mtext>s<\/o:mtext>\n                        <o:mtext>\u2009<\/o:mtext>\n                        <o:mtext>d<\/o:mtext>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>1.81<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>). At the start of the intervention, six infants (three in both groups) did not demonstrate initiation of goal-directed contralesional upper limb movements. During the intervention one infant receiving EI-UL and all three infants receiving EI-UL with integrated MuSSAP training started to initiate goal-directed movements. Conclusion. The results suggest manual ability of infants with unilateral brain lesion improved with both interventions. We hypothesize that the integrated MuSSAP training may facilitate attention and initiation of contralesional upper limb goal-directed movements. This trial is registered with NCT05533476).<\/jats:p>","DOI":"10.1155\/2023\/8128407","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T22:35:08Z","timestamp":1673044508000},"page":"1-12","source":"Crossref","is-referenced-by-count":9,"title":["Multisensory Stimulation and Priming (MuSSAP) in 4-10 Months Old Infants with a Unilateral Brain Lesion: A Pilot Randomised Clinical Trial"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3983-4769","authenticated-orcid":true,"given":"Anke P. M.","family":"Verhaegh","sequence":"first","affiliation":[{"name":"Department of Pediatric Rehabilitation, Sint Maartenskliniek, Nijmegen, Netherlands"},{"name":"Research Institute for Health Sciences, IQ healthcare, Radboud university medical center, Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8127-3857","authenticated-orcid":true,"given":"Brenda E.","family":"Groen","sequence":"additional","affiliation":[{"name":"Department of Research and Innovation, Sint Maartenskliniek, Nijmegen, Netherlands"},{"name":"Department of Rehabilitation, Donders Institute for Brain, Cognition and Behavior, Radboud university medical center, Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3603-4715","authenticated-orcid":true,"given":"Pauline B. M.","family":"Aarts","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rehabilitation, Sint Maartenskliniek, Nijmegen, Netherlands"},{"name":"Department of Research and Innovation, Sint Maartenskliniek, Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1134-8665","authenticated-orcid":true,"given":"Raymond","family":"van Ee","sequence":"additional","affiliation":[{"name":"Department of BioPhysics, Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7860-7791","authenticated-orcid":true,"given":"Mich\u00e8l A. A. P.","family":"Willemsen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Amalia Children\u2019s Hospital, Radboud university medical center, Nijmegen, Netherlands"},{"name":"Donders Institute for Brain, Cognition and Behavior, Radboud university medical center, Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7085-7497","authenticated-orcid":true,"given":"Marijtje L. A.","family":"Jongsma","sequence":"additional","affiliation":[{"name":"Behavioural Science Institute, Radboud University Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2637-6877","authenticated-orcid":true,"given":"Maria W. 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