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Infectious diseases characterized by swollen hock joints, movement disorders, and impaired growths have recently occurred in significant duck breeding areas in China. Infected ducks from Shandong Province were selected, and N-DRV-LY20 was isolated from the swollen joints. Next-generation sequencing (NGS) of N-DRV-LY20 and homology analysis showed that all ten fragments had the highest homology to N-DRV and the closest affinity to Duck\/N-DRV-XT18\/China\/2018. After artificial inoculation with N-DRV-LY20 virus solution, Cherry Valley ducks showed the same symptoms of leg swelling and hock joint deformation, which were not explored in previous studies. A long history of evolution has led to significant variation in DRV and altered its pathogenicity. In this study, we confirmed the ability of N-DRV to cause viral arthritis in ducks and clarified this isolate\u2019s genetic characteristics and level of variation, providing a basis for the control and variation detection of N-DRV.<\/jats:p>","DOI":"10.1155\/2023\/8179312","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T20:45:01Z","timestamp":1683751501000},"page":"1-12","source":"Crossref","is-referenced-by-count":5,"title":["Isolation and Pathogenicity Analysis of a Novel Orthoreovirus Caused the Outbreak of Duck Viral Arthritis in China"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8569-7486","authenticated-orcid":true,"given":"Bing","family":"Li","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Shandong Agricultural University, 61 Daizong Street, Tai\u2019an, Shandong Province 271018, China"},{"name":"Shandong Provincial Key Laboratory of Animal Biotechnology and 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