{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T21:05:14Z","timestamp":1775509514613,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T00:00:00Z","timestamp":1674259200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shanghai Municipal Commission of Health and Family Planning","award":["20224Y0317"],"award-info":[{"award-number":["20224Y0317"]}]},{"name":"Shanghai Municipal Commission of Health and Family Planning","award":["2022-65"],"award-info":[{"award-number":["2022-65"]}]},{"name":"Youth Medical Talents\u2014Clinical Laboratory Practitioner Program","award":["20224Y0317"],"award-info":[{"award-number":["20224Y0317"]}]},{"name":"Youth Medical Talents\u2014Clinical Laboratory Practitioner Program","award":["2022-65"],"award-info":[{"award-number":["2022-65"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2023,1,21]]},"abstract":"<jats:p>Objective. To investigate the relationship between peripheral blood total bilirubin (TBIL) levels and the risk of primary open-angle glaucoma (POAG). Methods. This study was a cross-sectional, case-control study design. Between April 2021 and January 2022, 198 POAG patients and 205 healthy subjects were recruited from the EENT Hospital of Fudan University. Their clinical information (intraocular pressure, central corneal thickness, vertical cup-disk ratios (VCDR), and axial length) and demographic data were collected. Serum levels of TBIL were measured in enzymes using a Roche C702 biochemical analyzer. The POAG subgroups were classified by gender and VCDR: mild (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mtext>VCDR<\/a:mtext>\n                        <a:mo>\u2264<\/a:mo>\n                        <a:mn>0.64<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>), moderate (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mtext>VCDR<\/c:mtext>\n                        <c:mo>\u2264<\/c:mo>\n                        <c:mn>0.85<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>), and severe (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mtext>VCDR<\/e:mtext>\n                        <e:mo>&gt;<\/e:mo>\n                        <e:mn>0.85<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). Univariate and multivariate logistic regression analyses were performed. Results. The level of TBIL (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mn>11.58<\/g:mn>\n                        <g:mo>\u00b1<\/g:mo>\n                        <g:mn>5.16<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>\u2009\u03bcmol\/L) in the POAG group was higher than that in the control group (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mn>10.18<\/i:mn>\n                        <i:mo>\u00b1<\/i:mo>\n                        <i:mn>3.38<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>\u2009\u03bcmol\/L; <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>p<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.05<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>). In the male subgroup, TBIL was also significantly higher than in the normal control group; TBIL levels were lower in the mild subgroup (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mn>10.82<\/m:mn>\n                        <m:mo>\u00b1<\/m:mo>\n                        <m:mn>4.48<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>\u2009\u03bcmol\/L), followed by the moderate subgroup (<jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mn>12.00<\/o:mn>\n                        <o:mo>\u00b1<\/o:mo>\n                        <o:mn>5.55<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>\u2009\u03bcmol\/L) and the severe subgroup (<jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mn>14.47<\/q:mn>\n                        <q:mo>\u00b1<\/q:mo>\n                        <q:mn>5.45<\/q:mn>\n                     <\/q:math>\n                  <\/jats:inline-formula>\u2009\u03bcmol\/L). The results of the multivariate logistic regression analysis showed that high TBIL levels were a risk factor for male POAG, at 1.126 (95% CI 1.009\u20131.256). Pearson\u2019s analysis revealed that TBIL was positively correlated with intraocular pressure (<jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mi>r<\/s:mi>\n                        <s:mo>=<\/s:mo>\n                        <s:mn>0.134<\/s:mn>\n                     <\/s:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <u:mi>p<\/u:mi>\n                        <u:mo>=<\/u:mo>\n                        <u:mn>0.012<\/u:mn>\n                     <\/u:math>\n                  <\/jats:inline-formula>), VCDR (<jats:inline-formula>\n                     <w:math xmlns:w=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\">\n                        <w:mi>r<\/w:mi>\n                        <w:mo>=<\/w:mo>\n                        <w:mn>0.142<\/w:mn>\n                     <\/w:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <y:math xmlns:y=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\">\n                        <y:mi>p<\/y:mi>\n                        <y:mo>=<\/y:mo>\n                        <y:mn>0.046<\/y:mn>\n                     <\/y:math>\n                  <\/jats:inline-formula>), anterior chamber depth (<jats:inline-formula>\n                     <ab:math xmlns:ab=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M14\">\n                        <ab:mi>r<\/ab:mi>\n                        <ab:mo>=<\/ab:mo>\n                        <ab:mn>0.190<\/ab:mn>\n                     <\/ab:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <cb:math xmlns:cb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M15\">\n                        <cb:mi>p<\/cb:mi>\n                        <cb:mo>=<\/cb:mo>\n                        <cb:mn>0.014<\/cb:mn>\n                     <\/cb:math>\n                  <\/jats:inline-formula>), and axial length (<jats:inline-formula>\n                     <eb:math xmlns:eb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M16\">\n                        <eb:mi>r<\/eb:mi>\n                        <eb:mo>=<\/eb:mo>\n                        <eb:mn>0.179<\/eb:mn>\n                     <\/eb:math>\n                  <\/jats:inline-formula>, <jats:inline-formula>\n                     <gb:math xmlns:gb=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M17\">\n                        <gb:mi>p<\/gb:mi>\n                        <gb:mo>=<\/gb:mo>\n                        <gb:mn>0.019<\/gb:mn>\n                     <\/gb:math>\n                  <\/jats:inline-formula>) in the patients. However, no statistical difference (<jats:inline-formula>\n                     <ib:math xmlns:ib=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M18\">\n                        <ib:mi>p<\/ib:mi>\n                        <ib:mo>&lt;<\/ib:mo>\n                        <ib:mn>0.05<\/ib:mn>\n                     <\/ib:math>\n                  <\/jats:inline-formula>) was observed in the female patients with POAG. Conclusion. The results showed that high levels of TBIL may be related to the pathogenesis of POAG and that the severity of the disease is positively correlated, especially in male patients.<\/jats:p>","DOI":"10.1155\/2023\/8206298","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T16:50:06Z","timestamp":1674319806000},"page":"1-9","source":"Crossref","is-referenced-by-count":5,"title":["Association between Serum Total Bilirubin Level and Patients with Primary Open-Angle Glaucoma in China: A Cross-Sectional, Case-Control Study"],"prefix":"10.1155","volume":"2023","author":[{"given":"Mingxi","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yani","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6383-9012","authenticated-orcid":true,"given":"Wenjun","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6443-740X","authenticated-orcid":true,"given":"Shengjie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2016.12.003"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-1549(05)70248-0"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25423"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1991.01080080050026"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13789"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13745"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1556\/1646.10.2018.39"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1080\/13510002.2016.1140406"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-017-2396-0"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-10-22"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.12085"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2701539"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2020.04.033"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s13167-021-00265-y"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8063651"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2018.00488"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000001593"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1097\/NNR.0000000000000454"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.5551\/jat.RV17035"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1801243"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.5546\/aap.2021.eng.e18"},{"issue":"4","key":"22","first-page":"296","article-title":"The protective role of bilirubin in oxygen-radical diseases of the preterm infant","volume":"14","author":"T. 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