{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:54:39Z","timestamp":1747191279149,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Endocrinology"],"published-print":{"date-parts":[[2023,12,21]]},"abstract":"<jats:p>Background. Parathyroid carcinoma accounts for &lt;1% of cases of primary hyperparathyroidism (PHPT). This rare condition may present with severe hypercalcemia and bone complications such as osteoclastomas and pathologic fractures. Here, we present a rare condition of panhypopituitarism resulting from an osteoclastoma in the sphenoid bone that invaded the pituitary fossa due to parathyroid carcinoma. Case Report. A 47-year-old woman previously diagnosed with PHPT underwent a parathyroidectomy 6\u2009years earlier, with histological examination indicating a parathyroid adenoma. After surgery, she continued to exhibit high serum parathyroid hormone (PTH) and calcium levels, with the development of bone pain and spontaneous fractures. Imaging exams showed a large osteoclastoma of the sphenoid bone, invading the pituitary fossa, causing hypopituitarism. A new parathyroidectomy was performed, with histological confirmation of parathyroid carcinoma and regression of the osteoclastoma. Conclusion. This case illustrates an unusual presentation of parathyroid carcinoma, in which an osteoclastoma of the sphenoid bone caused hypopituitarism.<\/jats:p>","DOI":"10.1155\/2023\/8274108","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T23:50:06Z","timestamp":1703202606000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["Hypopituitarism due to a Large Osteoclastoma Arising from the Sphenoid Bone Invading the Pituitary Fossa in a Patient with Parathyroid Carcinoma"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1035-4921","authenticated-orcid":true,"given":"Leonardo","family":"Bandeira","sequence":"first","affiliation":[{"name":"FBandeira Endocrine Institute, Recife, Brazil"},{"name":"Grupo Fleury, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6930-0664","authenticated-orcid":true,"given":"Lucian Batista de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolic Bone Diseases, Agamenon Magalh\u00e3es Hospital, University of Pernambuco Medical School, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3652-0484","authenticated-orcid":true,"given":"Maria Vit\u00f3ria Silva de","family":"Lima","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolic Bone Diseases, Agamenon Magalh\u00e3es Hospital, University of Pernambuco Medical School, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3812-7643","authenticated-orcid":true,"given":"Daniella","family":"R\u00eago","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolic Bone Diseases, Agamenon Magalh\u00e3es Hospital, University of Pernambuco Medical School, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5529-1736","authenticated-orcid":true,"given":"Luiz","family":"Griz","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolic Bone Diseases, Agamenon Magalh\u00e3es Hospital, University of Pernambuco Medical School, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0290-0742","authenticated-orcid":true,"given":"Francisco","family":"Bandeira","sequence":"additional","affiliation":[{"name":"FBandeira Endocrine Institute, Recife, Brazil"},{"name":"Division of Endocrinology, Diabetes and Metabolic Bone Diseases, Agamenon Magalh\u00e3es Hospital, University of Pernambuco Medical School, Recife, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"doi-asserted-by":"publisher","key":"1","DOI":"10.1002\/jbmr.4682"},{"doi-asserted-by":"publisher","key":"2","DOI":"10.1002\/jbmr.4665"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.1002\/jbmr.4677"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.1016\/j.ando.2015.03.016"},{"doi-asserted-by":"publisher","key":"5","DOI":"10.2143\/tvg.58.10.5001336"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1530\/erc-22-0287"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.1016\/j.ando.2015.03.003"},{"doi-asserted-by":"publisher","key":"8","DOI":"10.1007\/s12022-022-09709-1"},{"doi-asserted-by":"publisher","key":"9","DOI":"10.1007\/s12020-017-1414-2"},{"doi-asserted-by":"publisher","key":"10","DOI":"10.1590\/0004-2730000003381"},{"doi-asserted-by":"publisher","key":"11","DOI":"10.1007\/s12149-023-01832-1"},{"doi-asserted-by":"publisher","key":"12","DOI":"10.1007\/s11926-015-0523-2"},{"doi-asserted-by":"publisher","key":"13","DOI":"10.1155\/2014\/837204"}],"container-title":["Case Reports in Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2023\/8274108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2023\/8274108.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crie\/2023\/8274108.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T23:50:16Z","timestamp":1703202616000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crie\/2023\/8274108\/"}},"subtitle":[],"editor":[{"given":"Toshihiro","family":"Kita","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2023,12,21]]},"references-count":13,"alternative-id":["8274108","8274108"],"URL":"https:\/\/doi.org\/10.1155\/2023\/8274108","relation":{},"ISSN":["2090-651X","2090-6501"],"issn-type":[{"type":"electronic","value":"2090-651X"},{"type":"print","value":"2090-6501"}],"subject":[],"published":{"date-parts":[[2023,12,21]]}}}