{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:58:29Z","timestamp":1785322709816,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T00:00:00Z","timestamp":1703548800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2023,12,26]]},"abstract":"<jats:p>Pancreatic gastrointestinal stromal tumors (PGISTs) are exceptionally rare, accounting for &lt;5% of extra-gastrointestinal stromal tumors (EGISTs) and &lt;1% of malignant pancreatic neoplasms. We present a unique case of concurrent double primary malignancies in a 46-year-old female with a history of recurrent myoepithelial carcinoma of the parotid gland, managed through surgical resection and adjuvant therapy. She presented with an enlarging abdominal mass, initially suggestive of pancreatic metastasis. Immunohistochemical analysis revealed positive staining for smooth-muscle actin (SMA) and CD34 in both parotid and pancreatic tissues. Importantly, CD117 expression was confined to the pancreatic tissue, confirming the diagnosis of PGIST rather than metastasis. Subsequently, a splenic-sparing distal pancreatectomy was performed, followed by immediate imatinib therapy. This case underscores the potential for the coexistence of rare primary malignancies with unique histopathological characteristics and organ involvement. When encountering a newly developed lesion in a distant organ, surgeons must consider the possibility of metastasis to guide therapeutic decision-making. Early diagnosis and appropriate intervention are paramount, particularly in the case of PGIST, given its infrequent presentation and clinical complexities.<\/jats:p>","DOI":"10.1155\/2023\/8274226","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T19:05:09Z","timestamp":1703617509000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["Rare Double Primary Malignancies: A Pancreatic Gastrointestinal Stromal Tumor Mimicking as a Metastatic Lesion of Myoepithelial Carcinoma of Parotid Gland"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0655-3784","authenticated-orcid":true,"given":"Vania Myralda Giamour","family":"Marbun","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Universitas Indonesia, General Surgery Department, Cipto Mangunkusumo Hospital, Diponegoro Street #71, Senen, Central Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4809-0063","authenticated-orcid":true,"given":"Indah","family":"Jamtani","sequence":"additional","affiliation":[{"name":"Consultant of Oncology Division of General Surgery Department Faculty of Medicine, Universitas Indonesia, General Surgery Department, Cipto Mangunkusumo Hospital, Diponegoro Street #71, Senen, Central Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3560-5590","authenticated-orcid":true,"given":"Ening","family":"Krisnuhoni","sequence":"additional","affiliation":[{"name":"Staff of Pathology Anatomy Department, Faculty of Medicine, Universitas Indonesia, Pathology Anatomy Department, Cipto Mangunkusumo Hospital, Diponegoro Street #71, Senen, Central Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0748-9884","authenticated-orcid":true,"given":"Sonar Soni","family":"Panigoro","sequence":"additional","affiliation":[{"name":"Staff of Digestive Division of General Surgery Department, Faculty of Medicine, Universitas Indonesia, General Surgery Department, Cipto Mangunkusumo Hospital, Diponegoro Street #71, Senen, Central Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-016-1025-x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2016.08.019"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v6.i9.175"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1186\/s40792-017-0308-0"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.14701\/ahbps.2023s1.ep-156"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2020.10.034"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1159\/000494553"},{"issue":"11","key":"8","doi-asserted-by":"crossref","first-page":"954","DOI":"10.4236\/jct.2017.811085","article-title":"Pancreatic gastrointestinal stromal tumour: a case report and review of the literature","volume":"08","author":"D. 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