{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:22:05Z","timestamp":1773966125250,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":355,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>The present study investigated the phytochemical content of <jats:italic>Hibiscus panduriformis<\/jats:italic>, <jats:italic>Alternanthera pungens<\/jats:italic>, and <jats:italic>Wissadula rostrata<\/jats:italic> and assessed their radical scavenging and anti\u2010inflammatory properties. n\u2010Hexane, dichloromethane (DCM), ethyl acetate, and methanol extracts were prepared from the powdered plant parts. The phytochemical analysis was performed using qualitative high\u2010performance thin\u2010layer chromatography, and polyphenols were quantified using well\u2010established methods. The anti\u2010inflammatory effect was by lipoxygenase inhibition, while the antiradical impact was evaluated through DPPH and ABTS radicals. Steroids, triterpenoids, flavonoids, and tannins were identified in the three plants. The highest phenolic content (95.67 \u00b1 2.19\u2009mg gallic acid equivalent\/g) was obtained in the methanolic extract of <jats:italic>W. rostrata<\/jats:italic>, while the lowest was measured in <jats:italic>H. panduriformis<\/jats:italic>. <jats:italic>H. panduriformis<\/jats:italic> was found to be highly rich in flavonoids (61.22 \u00b1 0.09\u2009mg rutin equivalent\/g), condensed tannins (62.53 \u00b1 0.03\u2009mg catechin equivalent\/g), and hydrolyzable tannins (125.1 \u00b1 1.02\u2009mg tannic acid equivalent\/g). The methanolic extract of <jats:italic>H. panduriformis<\/jats:italic> displayed the greatest antilipoxygenase activity with an IC<jats:sub>50<\/jats:sub> value of 8.78 \u00b1 1.05\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL. It should be noted that although a moderate to low effect was observed, the extracts were more likely to scavenge DPPH (IC<jats:sub>50<\/jats:sub> values ranged from 0.106 \u00b1 0.010 to 1\u2009mg\/mL) than ABTS radicals. There was a strong to moderate correlation between the antilipoxygenase and DPPH radical scavenging effects of the methanolic extracts and total phenolic content (antilipoxygenase, <jats:italic>r<\/jats:italic> = 0.7175; DPPH, <jats:italic>r<\/jats:italic> = 0.9376). Furthermore, it is worth noting that this is the first report investigating the phytochemical analysis and <jats:italic>in vitro<\/jats:italic> biological properties of <jats:italic>Hibiscus panduriformis<\/jats:italic>. The results highlighted the richness of this plant in polyphenols and demonstrated its high and moderate effects on lipoxygenase and DPPH radicals, respectively. To this intent, further <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> studies on this plant, along with exhaustive phytochemical analysis, are needed.<\/jats:p>","DOI":"10.1155\/2023\/8289750","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T23:50:06Z","timestamp":1703289006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phytochemical Study and <i>In Vitro<\/i> Biological Activities of <i>Hibiscus panduriformis<\/i> Burm. f. (Malvaceae), <i>Alternanthera pungens Kunth<\/i> (Amaranthaceae), and <i>Wissadula rostrata<\/i> (Schumach.) Hook. f. 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