{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T05:14:30Z","timestamp":1781673270531,"version":"3.54.5"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":43,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017549","name":"Science and Technology Innovation 2025 Major Project of Ningbo","doi-asserted-by":"publisher","award":["2022Z150"],"award-info":[{"award-number":["2022Z150"]}],"id":[{"id":"10.13039\/501100017549","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005315","name":"Natural Science Foundation of Ningbo Municipality","doi-asserted-by":"publisher","award":["202003N4269"],"award-info":[{"award-number":["202003N4269"]}],"id":[{"id":"10.13039\/501100005315","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Over the last decade, researchers have paid more and more attention to the natural compound curcumin for its potential application in anticancer therapy. However, the application of curcumin has been limited owing to its rapid metabolism in the body. HO\u20103867, a stable curcumin analog, shows potent antitumor activities against various tumor cells. Yet, information on HO\u20103867\u2019s impact on non\u2010small\u2010cell lung cancer (NSCLC) cells is lacking. Herein, we evaluated the cytotoxicity of HO\u20103867 in NSCLC cells. We discovered that HO\u20103867 suppressed the viability of NSCLC cells containing wild\u2010type p53. In NSCLC cells, HO\u20103867 promotes both apoptosis and ferroptosis, the latter of which is a newly discovered mode of cell death. Mechanically, HO\u20103867\u2010induced apoptosis relied on the inhibition of Mcl\u20101 and Bcl\u20102 and the upregulation of Bax. Moreover, NSCLC cells undergo ferroptosis when treated with HO\u20103867 via activating the p53\u2010DMT1 axis and suppressing GPX4. Additionally, HO\u20103867 caused an accumulation of reactive oxygen species (ROS) in NSCLC in a way that was dependent on the presence of iron. Our findings point to the possibility that HO\u20103867 might be employed as a therapeutic agent for treating NSCLC.<\/jats:p>","DOI":"10.1155\/2023\/8378581","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T02:50:05Z","timestamp":1676343005000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Curcumin Analog, HO\u20103867, Induces Both Apoptosis and Ferroptosis via Multiple Mechanisms in NSCLC Cells with Wild\u2010Type p53"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5464-5918","authenticated-orcid":false,"given":"Ling","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8684-6485","authenticated-orcid":false,"given":"Guodong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1747-665X","authenticated-orcid":false,"given":"Ni","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6210-9816","authenticated-orcid":false,"given":"Linwen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6980-2752","authenticated-orcid":false,"given":"Guofeng","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,13]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.9"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25183"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/35037710"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14112745"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-019-0164-5"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8832043"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104919"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu11122989"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-022-03666-1"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.150367"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-021-01010-y"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-016-0312-4"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.158"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-018-0288-x"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.010"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.04.003"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-13-2433"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/cad.0000000000000470"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17248"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14061257"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041046"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.12.9.17713"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms151221703"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.183681"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566523219666190628152137"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-021-02178-z"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13904"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0261370"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.ra117.000950"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph14090942"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910560315"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds207"},{"key":"e_1_2_9_35_2","first-page":"1542","article-title":"Red and processed meat consumption and the risk of lung cancer: a dose-response meta-analysis of 33 published studies","volume":"7","author":"Xue X. 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