{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:11:43Z","timestamp":1787062303259,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2023,6,7]]},"abstract":"<jats:p>\n                    Background and Aim. Pain control is an integral part of dental treatment. The majority of patients complain of pain after endodontic procedures. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed for postoperative pain management and are available in various forms. Ketoprofen transdermal patch (KTP) has been limitedly investigated for pain control after endodontic treatments. The aim of this study was to compare the efficacy of KTP versus ibuprofen tablets for pain control after single-visit endodontic treatment of mandibular molars with irreversible pulpitis. Materials and Methods. In this randomized clinical trial, 64 patients who had mandibular first and second\u2009molars with irreversible pulpitis were randomly divided into two groups (n\u2009=\u200932) by stratified permuted block randomization. The experimental group used 60\u2009mg KTP every 6\u2009hours, and the control group received 400\u2009mg ibuprofen tablets every 6\u2009hours for 1\u2009day. The severity of pain experienced by patients was quantified before and at 2, 4, 8, 12, 24, and 48\u2009hours after endodontic treatment, using the numerical rating scale (NRS). Data were analyzed by using the t-test, Mann\u2013Whitney test, and generalized estimating equation (GEE) (alpha\u2009=\u20090.05). Results. The pain score was not significantly different between the two groups at the baseline or any other postoperative time point (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&gt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ). The reduction in the pain score was significant in both groups from 2 to 10\u2009hours and 10 to 48\u2009hours, postoperatively (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.001<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ). The interaction effect of time and group was not significant on the postoperative pain score in the abovementioned time intervals, and the pattern of pain reduction was the same over time in both groups (\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&gt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ). Conclusion. Both KTP and ibuprofen effectively decreased postendodontic pain. Considering the comparable pattern of pain reduction, KTP can be used as an alternative to ibuprofen tablets for effective pain control after endodontic treatment of mandibular first and second\u2009molars with irreversible pulpitis.\n                  <\/jats:p>","DOI":"10.1155\/2023\/8549655","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T10:20:11Z","timestamp":1686133211000},"page":"1-10","source":"Crossref","is-referenced-by-count":5,"title":["Analgesic Efficacy of Ketoprofen Transdermal Patch versus Ibuprofen Oral Tablet on Postendodontic Pain in Patients with Irreversible Pulpitis: A Randomized Clinical Trial"],"prefix":"10.1155","volume":"2023","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9403-0611","authenticated-orcid":true,"given":"Saeede","family":"Zadsirjan","sequence":"first","affiliation":[{"name":"Department of Endodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences Tehran, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4424-5785","authenticated-orcid":true,"given":"Amirhossein","family":"Toghrolian","sequence":"additional","affiliation":[{"name":"Student Research Committee, Guilan University of Medical Sciences, Guilan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4109-5128","authenticated-orcid":true,"given":"Nazanin","family":"Zargar","sequence":"additional","affiliation":[{"name":"Department of Endodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences Tehran, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","volume-title":"Orofacial Pain: From Basic Science to Clinical Management: the Transfer of Knowledge in Pain Research to Education","author":"B. 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Diwan","year":"2019","journal-title":"Indian Journal of Dental Research: Official Publication Of Indian Society For Dental Research"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-016-0941-3"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-017-1048-1"},{"issue":"11","key":"45","first-page":"27","article-title":"Comparative evaluation of analgesic efficacy of oral diclofenac sodium and transdemal patch (nupatch\u00ae) after periodental flap surgery: a randomized cross over clinical trial","volume":"7","author":"K. Kripal","year":"2019","journal-title":"International Journal of Scientific Research"}],"container-title":["Pain Research and Management"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/prm\/2023\/8549655.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/prm\/2023\/8549655.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/prm\/2023\/8549655.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T10:20:30Z","timestamp":1686133230000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/prm\/2023\/8549655\/"}},"subtitle":[],"editor":[{"given":"Sivakumar","family":"Nuvvula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,6,7]]},"references-count":45,"alternative-id":["8549655","8549655"],"URL":"https:\/\/doi.org\/10.1155\/2023\/8549655","relation":{},"ISSN":["1918-1523","1203-6765"],"issn-type":[{"value":"1918-1523","type":"electronic"},{"value":"1203-6765","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6,7]]}}}